Informace o publikaci

A Whole-Brain Model of the Aging Brain During Slow Wave Sleep

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LUPI Eleonora GABRIELE Di Antonio ANGIOLELLI Marianna SACHA Maria KAYABAS Mehmet Alihan ALBORE Nicola LEONE Riccardo KARIM El Kanbi DESTEXHE Alain FOUSEK Jan

Rok publikování 2024
Druh Článek v odborném periodiku
Časopis / Zdroj ENEURO
Fakulta / Pracoviště MU

Středoevropský technologický institut

Citace
www https://doi.org/10.1523/ENEURO.0180-24.2024
Doi http://dx.doi.org/10.1523/ENEURO.0180-24.2024
Klíčová slova Aging;Slow-wave sleep;Whole-brain modeling;Structural connectivity;Inter-hemispheric connectivity
Popis Age-related brain changes affect sleep and are reflected in properties of sleep slow-waves, however, the precise mechanisms behind these changes are still not completely understood. Here, we adapt a previously established whole-brain model relating structural connectivity changes to resting state dynamics, and extend it to a slow-wave sleep brain state. In particular, starting from a representative connectome at the beginning of the aging trajectory, we have gradually reduced the inter-hemispheric connections, and simulated sleep-like slow-wave activity. We show that the main empirically observed trends, namely a decrease in duration and increase in variability of the slow waves are captured by the model. Furthermore, comparing the simulated EEG activity to the source signals, we suggest that the empirically observed decrease in amplitude of the slow waves is caused by the decrease in synchrony between brain regions.
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