Informace o publikaci
Transforming Stroke and Microplastic Research: CT & LA-ICP-MS Unlock 3D Chemical Insights
| Autoři | |
|---|---|
| Rok publikování | 2024 |
| Druh | Vyžádané přednášky |
| Fakulta / Pracoviště MU | |
| Citace | |
| Přiložené soubory | |
| Popis | Over recent decades, the investigation of elemental, metallic, and protein distributions in biological tissues has gained prominence, especially within pharmaceutical and biomedical research [1]. This field has prioritized the development of targeted diagnostic and therapeutic interventions for cerebrovascular diseases, including ischemic stroke, a leading cause of mortality in developed nations. Given the critical need for early intervention, the study of novel drugs and their therapeutic impact is paramount. The combined use of computed tomography (CT) and laser ablation inductively coupled plasma mass spectrometry (LA-ICP-MS) provides a powerful framework for evaluating the efficacy of stroke treatments. This dual-modality imaging approach not only enables high-resolution 3D visualization of pathological tissues but also allows for chemical analysis of specific brain structures, revealing progression markers such as hemorrhage, vessel recanalization, and clot dissolution rates. Moreover, LA-ICP-MS offers a promising analytical approach for detecting marker metals in polymers [2] and identifying polymer alterations. [3] However, the direct application of LA-ICP-MS for the detection of microplastics (MPs) has been relatively limited, primarily focusing on the monitoring of trace metals adsorbed on MPs. [4] This study aims to advance the detection and imaging of MPs in biological tissues, thereby opening new avenues for tracking the presence of MPs in the human body and assessing their potential impacts on human health. This research underscores the critical need to understand the interactions between microplastics and biological systems to mitigate potential health risks. |
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