Informace o publikaci
NANOPARTICLES AS A NEW TOOL TO DIAGNOSE ISCHEMIC STROKE
| Autoři | |
|---|---|
| Rok publikování | 2024 |
| Druh | Další prezentace na konferencích |
| Fakulta / Pracoviště MU | |
| Citace | |
| Přiložené soubory | |
| Popis | Ischemic stroke (IS) was identified as the second most common cause of death worldwide in 2019 according to a survey [1]. A significant percentage of patients remain with permanent consequences that can persist even fifteen years after the event [2]. This is also associated with economic impacts on healthcare and supportive services, which amounted to approximately 60 billion euros in the EU in 2017 [3]. The key to success is time. IS can already be precisely diagnosed nowadays. However, in each specific situation, there is a problem with detecting the onset of stroke, which is crucial for choosing the appropriate treatment and thus saving lives. Today’s commonly used medical scanning devices can only visualize clots with high erythrocyte content. Other forms of thrombi become exceedingly difficult to recognize [4]. Polyiodinated biodegradable nanoparticles (IoNPs) have the potential to solve this problem. The current preliminary phase of research is focused on the distribution of elements in selected organs of laboratory animals. For the creation of an element distribution map, the unique method LA-ICP-MS is used in combination with µCT 3D volumetry results of the brain. Results to date show the success of the functioning analysis method and nanoparticles detection in the laboratory rat's bloodstream, livers, and spleens. A new technique for radiocontrast staining using caesium was developed. |
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