ACE gene I/D polymorphism and pulmonary disease severity in UK and Czech sarcoidosis populations

• Autoři: MCGRATH Deirdre; FOLEY Patrick J; PETREK Martin; IZAKOVIČOVÁ HOLLÁ Lydie; KOLEK Vítězslav; VEERARAGHAVAN Srihari; LYMPANY Penelope A; PANTELIDIS Panagiotis; VAŠKŮ Anna; WELLS Athol U; WELSH Kenneth I; DU BOIS Roland M
• Rok publikování: 2001
• Druh: Článek v odborném periodiku
• Časopis / Zdroj: Am.J.Respir.Crit.Care Med
• Fakulta / Pracoviště MU: Lékařská fakulta
• Obor: Pneumologie
• Klíčová slova: gene; polymorphism; ACE; sarcoidosis; severity; disease susceptibility
• Popis: Previous studies of the Insertion/Deletion (I/D) polymorphism of the Angiotensin-Converting Enzyme (ACE) gene in sarcoidosis have revealed both ethnic heterogeneity of I/D frequencies and controversy surrounding the association between the polymorphism and severity of disease. The objective of this study was, therefore, to clarify the role of the ACE I/D polymorphism in, 1) disease susceptibility, 2) pulmonary disease severity (with particular reference to pulmonary fibrosis) and 3) pulmonary disease progression, in two distinct European sarcoidosis populations.

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