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Computer modelling of effect of transversal tubules on excitation - contraction coupling in cardiac cells (Basic study)

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PÁSEK Michal CHRISTÉ Georges ŠIMURDA Jiří

Rok publikování 2001
Druh Článek ve sborníku
Konference Engineering Mechanics 2001
Fakulta / Pracoviště MU

Lékařská fakulta

Citace
Obor Biofyzika
Klíčová slova cardiac cell; T-system; quantitative modelling
Popis The transverse tubular system (T-system) of cardiac muscle is a structure that allows rapid propagation of excitation into the cell interior. As suggested in many resent experimental works it could have a significant effect on cardiac cell function induced by the accumulation or the depletion of ions in restricted tubular space. The aim of our work was to design a mathematical model of electrical activity of cardiac cell including a quantitative description of T-system function and to explore the physio-logical significance of T-system in excitation-contraction coupling quantitatively.
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