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Informace o publikaci
Synthesis of New 4-(4-(4-Methoxyphenyl)-5-(2-phenylquinazolin-4-yl)-1,3-Thiazol-2-yl)morpholine and N4-(5-(4-Methoxyphenyl)-1,3-oxathiol-2-yliden)-(2-phenylquinazolin-4-yl)-amine
Autoři | |
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Rok publikování | 2002 |
Druh | Článek v odborném periodiku |
Časopis / Zdroj | Heterocyclic Communications |
Fakulta / Pracoviště MU | |
Citace | |
Obor | Organická chemie |
Klíčová slova | quinazolines; 1;3-oxathioles; 1;3-thiazoles; domino-reaction; cyclization; retro-cyclization |
Popis | The reaction of N3,N3-(3-oxapentan-1,5-diyl)-N1-(2-phenyl-3,4-dihydroquinazolin-4-yliden)thiourea with 4-methoxyphenacyl bromide afforded either the kinetically controlled reversible reaction product N4-[5-(4-methoxyphenyl)-1,3-oxathiol-2-yliden]-(2-phenylquinazolin-4-yl)-amine or the thermo-dynamically controlled reaction product 4-[4-(4-methoxyphenyl)-5-(2-phenylquinazolin-4-yl) -4,5-dihydro-1,3-thiazol-2-yl]morpholine via domino-reaction by two different reaction pathways. |
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