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Changes in the cytoskeleton of P19 cells during apoptosis associated with induced differentiation

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NERADIL Jakub VESELSKÁ Renata SVOBODA Augustin

Rok publikování 2002
Druh Článek ve sborníku
Konference Cells IV
Fakulta / Pracoviště MU

Lékařská fakulta

Citace
Obor Morfologické obory a cytologie
Klíčová slova induced differentiation; apoptosis; cytoskeleton; P19 cell line; retinoic acid; dimethylsulfoxide; actin filaments; microtubules
Popis The aim of the work was to study the morphology of microtubules and actin filaments during the apoptosis accompanying the differentiation of P19 cells. Mesodermal differentiation was induced by dimtehylsulfoxide and retinoic acid was used for induction of neuronal differentiation. To summarize, actin cytoskeleton actively participates in the executive phase of apoptosis whereas microtubules are only passively degraded in consequence of tubulin proteolysis.
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