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Effects of CB2receptor agonist palmitoylethanolamide and CB2receptor antagonist AM 630 on leukocyte phagocytic activity in mice

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VINKLEROVÁ Jana ŠULCOVÁ Alexandra

Rok publikování 2002
Druh Článek v odborném periodiku
Časopis / Zdroj Behavioural Pharmacology
Fakulta / Pracoviště MU

Lékařská fakulta

Citace
Obor Farmakologie a lékárnická chemie
Klíčová slova cannabinoids; palmitoylethanolamide; AM 630; leukocyte phagocytosis; chemiluminescence; mice
Popis The cannabinoids are involved in regulation of immune function. This action can be mediated either through cannabinoid receptors which subtypes CB1 and CB2 have been identified on leukocytes, or by non-receptor mechanism not clearly understood yet. The present study investigated th influence of the CB2 receptor agonist palmitoylethanolamide and the CB2 receptor antagonist AM 630 on the cellular immune function on leukocyte phagocytosis. Phagocytic activity of mouse leukocytes was measured in chemiluminescence (CL) assay using zymosan induction of phagocytosis and luminol potentiated of CL in vitro.
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