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Differential effects of v-Jun and c-Jun proteins on v-myb-transformed monoblasts
Autoři | |
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Rok publikování | 2002 |
Druh | Článek v odborném periodiku |
Časopis / Zdroj | Cellular and Molecular Life Sciences |
Fakulta / Pracoviště MU | |
Citace | |
Obor | Genetika a molekulární biologie |
Klíčová slova | v-Myb; Jun; differebtiation; proliferation; retinoic acid; phorbol ester |
Popis | The line of v-myb-transformed chicken monoblats BM2 can be induced to terminal differentiation using phorbol esters. The fact that Jun proteins are up-regulated in the phorbol ester-treated BM2 cells promptred us to investigate the role of the Jun proteins in regulation of myeloid differentiation. We ectopically expressed v-jun and c-jun in BM2 cells and evaluated their effects on differentiation, proliferation and apoptosis. |
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