Informace o publikaci
Synthesis of trihydroxylated pyrrolizidine using 1,3-dipolar cycloaddition of D-erythrose derived nitron
| Autoři | |
|---|---|
| Rok publikování | 2001 |
| Druh | Článek v odborném periodiku |
| Časopis / Zdroj | Synlett |
| Fakulta / Pracoviště MU | |
| Citace | |
| Popis | A route has been developed for the synthesis of enantiomerically and diastereomerically pure trihydroxylated pyrrolizidines. A chiral sugar derived nitrone undergoes diastereoselective dipolar cycloaddition with methyl acrylate to afford erythro-cis isoxazolidine a suitable cycloadduct undergoes N-O cleavage and recyclization to (1S.2R.6R.7aS)-trihydroxylated pyrrolizidine |