Informace o publikaci

Mitochondrial uncoupling protein in brown adipocytes differentiated in cell culture

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KOPECKÝ Jan BAUDYŠOVÁ Marie PAVELKA Stanislav ZANOTTI Francesco JANÍKOVÁ Dagmar HOUŠTĚK Josef

Rok publikování 1991
Druh Článek v odborném periodiku
Časopis / Zdroj Journal of Cellular Biochemistry [IF=2.778 (1990)]
Fakulta / Pracoviště MU

Přírodovědecká fakulta

Citace
Obor Biochemie
Klíčová slova Biogenesis; brown adipose tissue; thermogenic mitochondria; uncoupling protein
Popis Differentiation of precursor cells isolated from mouse brown adipose tissue was studied in cell culture, in order to characterize the biogenesis of unique thermogenic mitochondria. Synthesis of mitochondrial uncoupling protein (UCP), F1-ATPase, and cytochrome oxidase was examined by L-[35S]methionine labeling and immunoblotting. In these cells, it was possible, by using norepinephrine, to induce specifically the synthesis of the UCP but not of F1-ATPase or cytochrome oxidase.

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