Informace o publikaci

PREDICTIVE PARAMETERS OF THE PHARYNX AND SUPRAGLOTTIC CARCINOMAS

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SMILEK Pavel KOSTŘICA Rom ROTTENBERG Jan VESELÝ Karel DUŠEK Ladislav

Rok publikování 2005
Druh Článek ve sborníku
Konference Sborník abstrakt a program 68. kongresu České spol. pro otorinolaryngologii a chir. hlavy a krku
Fakulta / Pracoviště MU

Lékařská fakulta

Citace
Obor ORL, oftalmologie, stomatologie
Klíčová slova head and neck cancer; prognosis; p53; DNA flow-cytometry
Popis The analysis was carried out with a set of 60 patients suffering from carcinoma of the pharynx and supraglottis. Besides routine examinations, flow cytometric analysis of was performed, p53 and Ki-67 markers were established by means of immunohistochemistry. Furthermore mitotic and apoptotic index were established. Cytokinetic parameters and proliferation activity were found as important predictors of the second level (after recognizing stage, grade and DNA status of the tumor). Early progressed cases have typically decreased SPF fraction combined with increased mitotic activity.

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