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Depression, cortisol and somatoform dissociative symtoms

Název česky Deprese, kortizol a somatoformní disociativní symptomy
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BOB Petr FREYBERGH PF JAŠOVÁ D. ŠUSTA M. PAVLAT J. ZIMA T. BENAKOVÁ H. BIZIK G. SVĚTLÁK Miroslav VEVERA J. MIKLOŠKO J. HÁJEK K. RABOCH J.

Rok publikování 2008
Druh Článek v odborném periodiku
Časopis / Zdroj NEUROENDOCRINOLOGY LETTERS
Fakulta / Pracoviště MU

Lékařská fakulta

Citace
Obor Neurologie, neurochirurgie, neurovědy
Klíčová slova Depression cortisol and somatoform dissociative symtoms
Popis OBJECTIVE: According to recent findings neuroendocrine response related to dissociative symptoms is related to dysregulation of the hypothalamus-pituitary-adrenal (HPA) axis but HPA axis functioning as related to dissociation is only partially understood. METHOD: With the aim to test the relationship between basal serum cortisol and dissociative symptoms measured as somatoform and psychic dissociation we performed clinical testing and biochemical analysis in 30 inpatients with diagnosis of unipolar depression (mean age 41.46, SD=13.68). RESULTS: The results show that cortisol as an index of HPA axis functioning manifests significant relationship to somatoform dissociative symptoms (r=-0.40; p=0.014). CONCLUSIONS: The result indicates relationship between HPA-axis reactivity and somatoform dissociative symptoms in unipolar depressive patients and suggests that somatoform dissociation presents a defense mechanism related to a passive coping response.
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