Informace o publikaci
DNA modifications by antitumor trans-[PtCl2(E-iminoether)(2)]
| Autoři | |
|---|---|
| Rok publikování | 1997 |
| Druh | Článek v odborném periodiku |
| Časopis / Zdroj | MOLECULAR PHARMACOLOGY |
| Fakulta / Pracoviště MU | |
| Citace | |
| Obor | Farmakologie a lékárnická chemie |
| Klíčová slova | INTERSTRAND CROSS-LINKS; ANTI-TUMOR ACTIVITY; PLATINUM COMPLEXES; IN-VITRO; CISPLATIN; BINDING; CIS-DIAMMINEDICHLOROPLATINUM(II); ADDUCTS; CYTOTOXICITY; ANTIBODIES |
| Popis | Recent findings that an analogue of clinically ineffective transplatin, trans-[PtCl2(E-iminoether)(2)], exhibits antitumor activity has helped reevaluation of the empirical structure-antitumor activity relationship generally accepted for platinum(II) complexes. According to this relationship, only the cis geometry of leaving ligands in the bifunctional platinum(II) complexes, should be therapeutically active. Global modifications of natural DNAs in cell-free media by trans-[PtCl2(E-iminoether)(2)] were studied through various molecular biophysical methods and compared with modifications by cis-[PtCl2(E-iminoether)(2)], transplatin, cisplatin, and monofunctional chlorodiethylenetriamineplatinum(II) chloride. |