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Bile Duct Malignancies

Název česky Malignity žlučových cest.
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TUČEK Štěpán TOMÁŠEK Jiří HALÁMKOVÁ Jana KISS Igor ANDRAŠINA Tomáš HEMMELOVÁ Beáta ADÁMKOVÁ KRÁKOROVÁ Dagmar VYZULA Rostislav

Rok publikování 2010
Druh Článek v odborném periodiku
Časopis / Zdroj Klinicka onkologie
Fakulta / Pracoviště MU

Lékařská fakulta

Citace
Obor Onkologie a hematologie
Klíčová slova bile duct neoplasms – cholangiocarcinoma – gallbladder cancer – palliative treatment
Popis Bile duct malignancies include intrahepatic cholangiocarcinoma (ICC), extrahepatic cholangiocarcinoma (ECC), gall bladder carcinoma (GC) and carcinoma of Vater’s ampulla (ampulloma). Bile duct neoplasms are rare tumours with overall poor prognosis. The overall incidence aff ects up to 12.5 per 100,000 persons in the Czech Republic. The mortality rate has risen recently to 9.5 per 100,000 persons. The incidence and mortality have been remarkably stable over the past 3 decades. The survival rate of patients with these tumours is poor, usually not exceeding 12 months. The diagnostic process is complex, uneasy and usually late. Most cases are diagnosed when unresectable, and palliative treatment is the main approach of medical care for these tumours. The treatment remains very challenging. New approaches have not brought much improvement in this fi eld. Standards of palliative care are lacking and quality of life assessments are surprisingly not common. From the scarce data it seems, however, that multimodal individually tailored treatment can prolong patients’ survival and improve the health-related quality of life. The care in specialized centres off ers methods of surgery, interventional radiology, clinical oncology and high quality supportive care. These methods are discussed in the article in greater detail. Improvements in this fi eld can be sought in new diagnostic methods and new procedures in surgery and interventional radiology. Understanding the tumour bio logy on the molecular level could shift the strategy to a more successful one, resulting in more cured patients. Further improvements in palliative care can be sought by defi ning new targets and new drug development. The lack of patients with bile duct neoplasms has been the limiting factor for any improvements. A new design of larger randomized international multicentric clinical trials with prompt data sharing could help to overcome this major problem. Defi ning standards of palliative care is a necessity. Addressing health-related quality of life could help to assess the real benefi t of palliative treatment.

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