Informace o publikaci

Birth order and risk of non-hodgkin lymphoma - true association or bias?

Autoři	GRULICH A. E. VAJDIC C. M. FALSTER M. KANE E. SMEDBY K. BRACCI P. DE SANJOSE S. BECKER N. TURNER J. MARTINEZ-MAZA O. MELBYE M. ENGELS E. VINEIS P. COSTANTINI A. HOLLY E. SPINELLI J. LA VECCHIA C. ZHENG T. CHIU B. FRANCESCHI S. COCCO P. MAYNADIE M. FORETOVÁ Lenka STAINES A. BRENNAN P. DAVIS S. SEVERSON R. CERHAN J. BREEN E. BIRMANN B. COZEN W.
Rok publikování	2010
Druh	Článek v odborném periodiku
Časopis / Zdroj	American journal of epidemiology
Fakulta / Pracoviště MU	Lékařská fakulta
Citace
Doi	http://dx.doi.org/10.1093/aje/kwq167
Obor	Onkologie a hematologie
Klíčová slova	birth order; case-control studies; lymphoma; non-Hodgkin; selection bias; social class
Popis	There is inconsistent evidence that increasing birth order may be associated with risk of non-Hodgkin lymphoma (NHL). The authors examined the association between birth order and related variables and NHL risk in a pooled analysis (1983-2005) of 13,535 cases and 16,427 controls from 18 case-control studies within the International Lymphoma Epidemiology Consortium (InterLymph). Overall, the authors found no significant association between increasing birth order and risk of NHL (P-trend = 0.082) and significant heterogeneity. However, a significant association was present for a number of B- and T-cell NHL subtypes. There was considerable variation in the study-specific risks which was partly explained by study design and participant characteristics. In particular, a significant positive association was present in population-based studies, which had lower response rates in cases and controls, but not in hospital-based studies. A significant positive association was present in higher-socioeconomic-status (SES) participants only. Results were very similar for the related variable of sibship size. The known correlation of high birth order with low SES suggests that selection bias related to SES may be responsible for the association between birth order and NHL.