Informace o publikaci

Optimizing the use of lenalidomide in relapsed or refractory multiple myeloma: consensus statement

Autoři	DIMOPOULOS MA. PALUMBO A. ATTAL M. BEKSAÇ M. DAVIES FE. DELFORGE M. EINSELE H. HÁJEK Roman HAROUSSEAU J.L. LEAL DA COSTA F. LUDWIG H. MELLQVIST U.H. MORGAN G.J. SAN-MIGUEL Jesus ZWEEGMAN S. SONNEVELD P.
Rok publikování	2011
Druh	Článek v odborném periodiku
Časopis / Zdroj	Leukemia
Fakulta / Pracoviště MU	Lékařská fakulta
Citace
Doi	http://dx.doi.org/10.1038/leu.2011.3
Obor	Onkologie a hematologie
Klíčová slova	multiple myeloma; relaps; lenalidomide
Popis	An expert panel convened to reach a consensus regarding the optimal use of lenalidomide in combination with dexamethasone (Len/Dex) in patients with relapsed or refractory multiple myeloma (RRMM). On the basis of the available evidence, the panel agreed that Len/Dex is a valid and effective treatment option for most patients with RRMM. As with other therapies, using Len/Dex at first relapse is more effective regarding response rate and durability than using it after multiple salvage therapies. Len/Dex may be beneficial regardless of patient age, disease stage and renal function, although the starting dose of lenalidomide should be adjusted for renal impairment and cytopenias. Long-term treatment until there is evidence of disease progression may be recommended at the best-tolerated doses of both lenalidomide and dexamethasone. Recommendations regarding the prevention and management of adverse events, particularly venous thromboembolism and myelosuppression, were provided on the basis of the available evidence and practical experience of panel members. Ongoing trials will provide more insight into the effects of continuous lenalidomide-based therapy in myeloma.