Centrosome associated genes in multiple myeloma

• Autoři: KRYUKOV Fedor; NĚMEC Pavel; DEMENTYEVA Elena Vladimirovna; ŠEVČÍKOVÁ Sabina; ALMÁŠI Martina; SMETANA Jan; KUGLÍK Petr; HÁJEK Roman
• Rok publikování: 2011
• Druh: Konferenční abstrakty
• Fakulta / Pracoviště MU: Lékařská fakulta
• Popis: Multiple myeloma (MM) is a lymphoproliferative disease characterized by clonal expansion of neoplastic plasma cells within the bone marrow. The genome of malignant plasma cells is extremely unstable characterized by a complex combination of structural and numerical abnormalities. It is suggested that centrosome abnormalities, of which centrosome amplification is the most prominent, occur early in MM pathogenesis and increase with disease progression. Centrosome amplification is therefore associated with deregulation of cell cycle, mitosis, DNA repair and proliferation. The objective of our study was to evaluate changes in expression profile of genes involved in centrosome structure/function in MM with known role in oncogenesis.In our study, we showed distinct cluster of 36 mitotic genes involved in centrosome abnormality in MM. Similarity of expression profile in revealed cluster gives us the possibility to suspect that these genes are involved in MM cell oncogenesis as a whole complex. This fact needs more detailed investigation and in our futher work we anticipate new insights into pathogenesis and possible crucial role of centrosome abnormalities in myeloma malignancy.

Související projekty

• Od klasických prognostických markerů ke klinicky aplikovatelným farmakogenomickým a farmakoproteomickým projektům u mnohočetného myelomu a monoklonálních gamapatií
• Úloha abnormalit chromozómu 1 a kaskády NF-kappaβ v patogenezi mnohočetného myelomu
• Úloha mitotické disrupce v B lymfocytech u mnohočetného myelomu