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Syntheses and reactivity of alkyl 1-[N-(2-chloro-5-nitro-phenyl)-benzimidoyl] thioureas
Autoři | |
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Rok publikování | 2012 |
Druh | Článek v odborném periodiku |
Časopis / Zdroj | Journal ofSulfur Chemistry |
Fakulta / Pracoviště MU | |
Citace | |
Doi | http://dx.doi.org/10.1080/17415993.2011.629094 |
Obor | Organická chemie |
Klíčová slova | thiourea–isothiourea rearrangement; SNAr reaction; benzimidoyl thiourea; benzothiazole |
Popis | A series of new alkyl 1-[N-(2-chloro-5-nitro-phenyl)-benzimidoyl] thioureas 3a–h were prepared from benzamides 1a–c. Benzimidoyl thioureas 3a–e afforded 5-nitro-2-phenyl-benzothiazole 5a–c under basic conditions via thiourea–isothiourea rearrangement and SNAr. A mechanistic rationalization supported by the direct formation of benzothioamide 8 and bis-benzimidoyl sulfide 9 derivatives from the reaction of imidoyl isothiocyanate 2 with bulky amines was supported. |