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Single nucleotide polymorphisms of matrix metalloproteinase 9 (MMP9) and tumor protein 73 (TP73) interact with Epstein-Barr virus in chronic lymphocytic leukemia: results from the European case-control study EpiLymph

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CASABONNE D. REINA O. BENAVENTE Yolanda BECKER Nikolaus MAYNADIE Marc FORETOVÁ Lenka COCCO Pierluigi GONZALEZ-NEIRA Anna NIETERS Alexandra BOFFETTA Paolo MIDDELDORP Jaap M. DE SANJOSE Silvia

Rok publikování 2011
Druh Článek v odborném periodiku
Časopis / Zdroj Haematologica
Fakulta / Pracoviště MU

Lékařská fakulta

Citace
Doi http://dx.doi.org/10.3324/haematol.2010.031161
Obor Onkologie a hematologie
Klíčová slova chronic lymphocytic leukemia; epidemiology; Epstein Barr virus; interaction; polymorphism
Popis Using EpiLymph case-control data, we found that chronic lymphocytic leukemia patients were more likely to have abnormal reactive serological patterns to Epstein Barr virus than controls. Here, we aimed to assess whether this association is modified by genetic variants. We examined 1,305 Single Nucleotide Polymorphisms from 300 selected genes related to various pathways in 240 cases and 513 controls from five European centers. In a recessive model, patients positive to aberrant antibody pattern and homozygous for rare genotypes in rs8113877T > G or rs17576A > G of the MMP9 gene were at highest risk of chronic lymphocytic leukemia. In a dominant model, TP73 showed the highest risk in patients positive to aberrant antibody pattern and homozygous for the wild-type genotype in rs1885859G > C or rs3765701A > T. All interactions were additive and no main effect was observed. The strong interactions observed may be indicative of a specific pathway in cancer genesis. Confirmation of these results is warranted.

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