Centrosomal Disruption As Early Event in Myeloma Development

• Autoři: ŠEVČÍKOVÁ Sabina; KRYUKOV Fedor; DEMENTYEVA Elena Vladimirovna; KUBICZKOVÁ Lenka; NĚMEC Pavel; ADAM Zdeněk; HÁJEK Roman
• Rok publikování: 2011
• Druh: Konferenční abstrakty
• Fakulta / Pracoviště MU: Lékařská fakulta
• Popis: Multiple myeloma (MM) is a malignancy of differentiated B-lymphocytes characterized by accumulation of clonal plasma cells (PCs) in the bone marrow. Genome of malignant PCs is extremely unstable and characterized by complex combination of structural and numerical abnormalities. The basis of genomic instability underlying MM is still unclear. Centrosome amplification (CA) is present in about a third of MM cases and may represent a mechanism leading to genomic instability in myeloma. We have previously shown that CA is present in pre-plasma cells stages of B-cell development. Aims: The objective of our study was to evaluate changes in expression of chosen key genes involved in centrosome duplication process in both B and PCs, including their possible changes during MM progression.

Související projekty

• Od klasických prognostických markerů ke klinicky aplikovatelným farmakogenomickým a farmakoproteomickým projektům u mnohočetného myelomu a monoklonálních gamapatií
• Úloha abnormalit chromozómu 1 a kaskády NF-kappaβ v patogenezi mnohočetného myelomu
• Úloha mitotické disrupce v B lymfocytech u mnohočetného myelomu