Detection of lymph node involvement in colorectal cancer patients by analysis of microRNA expression profiles.

• Autoři: SLABÝ Ondřej; FALTEJSKOVÁ Petra; HÉŽOVÁ Renata; SVOBODA Marek; NĚMEČEK Radim; BEŠŠE Andrej; ŠEVČÍKOVÁ Sabina; RADOVÁ Lenka; VYZULA Rostislav
• Rok publikování: 2011
• Druh: Konferenční abstrakty
• Fakulta / Pracoviště MU: Lékařská fakulta
• Popis: The aim of this study was molecular characterization of primary tumors of colon and rectum using modern and progressive analysis based on expression profiles of 667 microRNAs by quantitative real-time PCR arrays. We analyzed expression profiles of 20 patients without lymph node positivity and 25 patients with lymph node positivity to identify miRNA differentially expressed between these two groups that would alow us to diagnose presence of lymph nodes metastases directly from the primary tumor.