Informace o publikaci
MicroRNAs and Hepatocellular Carcinoma
| Autoři | |
|---|---|
| Rok publikování | 2012 |
| Druh | Kapitola v knize |
| Fakulta / Pracoviště MU | |
| Citace | |
| Popis | Hepatocellular carcinoma (HCC) is the fifth most prevalent cancer in the world and is the third leading cause of cancer-related death. Because of its high fatality rates, the incidence and mortality rates are almost equal. From these reasons, it is necessary to identify powerful biological markers that can be used to screen high-risk patients in order to allow better HCC detection, earlier intervention, and to increase the likelihood of successful treatment. Accumulating evidence has linked the dysregulated miRNA levels to a variety of malignancies, including HCC. Several investigations have also described the ability of specific miRNA expression profiles to predict prognosis, and potential of selected miRNAs as novel therapeutic targets in HCC patients. |