Mgr. Bohumil Fafílek, Ph.D.

2024

• Discovery of Two Highly Selective Structurally Orthogonal Chemical Probes for Activin Receptor-like Kinases 1 and 2

  NĚMEC Václav REMEŠ Marek BEŇOVSKÝ Petr BÖCK Michael Christopher ŠRANKOVÁ Eliška WONG Jong Fu JULIEN Cros WILLIAMS Eleanor TSE Lap Hang SMIL David ENSAN Deeba ISAAC Methvin B AL-AWAR Rima GOMOLKOVÁ Regína URSACHI Vlad-Constantin FAFÍLEK Bohumil KAHOUNOVA Zuzana VICHOVA Rachel VACEK Ondrej BERGER Benedict-Tilman WELLS Carrow I CORONA Cesear R VASTA James D ROBERS Matthew B KREJČÍ Pavel SOUČEK Karel BULLOCK Alex N KNAPP Stefan PARUCH Kamil

  Article in Periodical

  Journal of Medicinal Chemistry, year: 2024, volume: 67, edition: 15, DOI

• Ligand bias underlies differential signaling of multiple FGFs via FGFR1

  KARL Kelly NUALA Del Piccolo LIGHT Taylor ROY Tanaya DUDEJA Pooja URSACHI Vlad-Constantin FAFÍLEK Bohumil KREJČÍ Pavel HRISTOVA Kalina

  Article in Periodical

  elife, year: 2024, volume: 12, edition: April 2024, DOI

2022

• 4-PBA Treatment Improves Bone Phenotypes in the Aga2 Mouse Model of Osteogenesis Imperfecta

  DURAN I. ZIEBA J. CSUKASI F. MARTIN J. H. WACHTELL D. BARAD M. DAWSON B. FAFÍLEK Bohumil JACOBSEN C. M. AMBROSE C. G. COHN D. H. KREJČÍ Pavel LEE B. H. KRAKOW D.

  Article in Periodical

  Journal of bone and mineral research, year: 2022, volume: 37, edition: 4, DOI

• Expanding horizons of achondroplasia treatment: current options and future developments

  FAFÍLEK Bohumil BOSÁKOVÁ Michaela KREJČÍ Pavel

  Article in Periodical

  Osteoarthritis and Cartilage, year: 2022, volume: 30, edition: 4, DOI

• LuminoCell: a versatile and affordable platform for real-time monitoring of luciferase-based reporters

  WEISSOVÁ Kamila FAFÍLEK Bohumil RADASZKIEWICZ Tomasz Witold ÇELIKER Canan MACHÁČKOVÁ Petra ČECHOVÁ Tamara ŠEBESTÍKOVÁ Jana HAMPL Aleš BRYJA Vítězslav KREJČÍ Pavel BÁRTA Tomáš

  Article in Periodical

  Life science alliance, year: 2022, volume: 5, edition: 8, DOI

2021

• An RNA aptamer restores defective bone growth in FGFR3-related skeletal dysplasia in mice

  KIMURA T. BOSÁKOVÁ Michaela NONAKA Y. HRUBA Eva YASUDA K. FUTAKAWA S. KUBOTA T. FAFÍLEK Bohumil GREGOR Tomáš POOVAKULATHU ABRAHAM Sara GOMOLKOVÁ Regína BELASKOVA Silvie PEŠL Martin CSUKASI F. DURAN I. FUJIWARA M. KAVKOVA Michaela ZIKMUND Tomas KAISER Josef BUCHTOVÁ Marcela KRAKOW D. NAKAMURA Y. OZONO K. KREJČÍ Pavel

  Article in Periodical

  Science Translational Medicine, year: 2021, volume: 13, edition: 592, DOI

2020

• Elucidation of protein interactions necessary for the maintenance of the BCR-ABL signaling complex

  GREGOR Tomáš BOSÁKOVÁ Michaela NITĂ Alexandru POOVAKULATHU ABRAHAM Sara FAFÍLEK Bohumil ČERNOHORSKÁ Nicole RYNEŠ Jan TRANTÍRKOVÁ Silvie ŽÁČKOVÁ Daniela MAYER Jiří TRANTÍREK Lukáš KREJČÍ Pavel

  Article in Periodical

  Cellular and molecular life sciences, year: 2020, volume: 77, edition: 19, DOI

2019

• Fibroblast growth factor receptor influences primary cilium length through an interaction with intestinal cell kinase

  BOSÁKOVÁ Michaela NITĂ Alexandru GREGOR Tomáš VAŘECHA Miroslav GUDERNOVÁ Iva FAFÍLEK Bohumil BÁRTA Tomáš BASHEER Neha POOVAKULATHU ABRAHAM Sara BÁLEK Lukáš TOMANOVÁ Markéta FIALOVÁ KUČEROVÁ Jana BOSÁK Juraj POTĚŠIL David ZIEBA Jennifer SONG Jieun KONIK Peter PARK Sohyun DURAN Ivan ZDRÁHAL Zbyněk ŠMAJS David JANSEN Gert FU Zheng KO Hyuk Wan HAMPL Aleš TRANTÍREK Lukáš KRAKOW Deborah KREJČÍ Pavel

  Article in Periodical

  Proceedings of the National Academy of Sciences of the United States of America, year: 2019, volume: 116, edition: 10, DOI

2018

• The inositol phosphatase SHIP2 enables sustained ERK activation downstream of FGF receptors by recruiting Src kinases

  FAFÍLEK Bohumil BÁLEK Lukáš BOSÁKOVÁ Michaela VAŘECHA Miroslav NITĂ Alexandru GREGOR Tomáš GUDERNOVÁ Iva KŘENOVÁ Jitka GHOSH S. PISKÁČEK Martin JONATOVA Lucie ČERNOHORSKÁ Nicole ZIEBA J.T. KOSTAS M. HAUGSTEN E.M. WESCHE J. ERNEUX C. TRANTÍREK Lukáš KRAKOW D. KREJČÍ Pavel

  Article in Periodical

  SCIENCE SIGNALING, year: 2018, volume: 11, edition: 548, DOI

2017

• Inhibitor repurposing reveals ALK, LTK, FGFR, RET and TRK kinases as the targets of AZD1480

  GUDERNOVÁ Iva BÁLEK Lukáš VAŘECHA Miroslav FIALOVÁ KUČEROVÁ Jana BOSÁKOVÁ Michaela FAFÍLEK Bohumil PALUŠOVÁ Veronika ULDRIJAN Stjepan TRANTÍREK Lukáš KREJČÍ Pavel

  Article in Periodical

  Oncotarget, year: 2017, volume: 8, edition: 65, DOI