Mgr. Bohumil Fafílek, Ph.D.

2025

• Protein structure and interactions elucidated with in-cell NMR for different cell cycle phases and in 3D human tissue models

  RYNEŠ Jan IŠTVÁNKOVÁ Eva KRAFČÍKOVÁ Michaela LUCHINAT Enrico BARBIERI Letizia BANCI Lucia KAMARÝTOVÁ Kristýna LOJA Tomáš FAFÍLEK Bohumil RICO LLANOS Gustavo KREJČÍ Pavel MACUREK Libor TRANTÍRKOVÁ Silvie TRANTÍREK Lukáš

  Article in Periodical

  Communications Biology, year: 2025, volume: 8, edition: 1, DOI

• Specific inhibition of fibroblast growth factor receptor 1 signaling by a DNA aptamer

  ZLÍNSKÁ Vladimíra FEKETOVÁ Zuzana CZYREK Aleksandra Anna CHUDZIAN Julia ZIVKOVIC Martina Lenarcic URSACHI Vlad-Constantin DUDEJA Pooja FAFÍLEK Bohumil RYNEŠ Jan RICO LLANOS Gustavo KOUDELKA Adolf ROY Tanaya BIADUN Martyna RAŠKOVÁ Vendula SVOZILOVÁ Kateřina STROBLOVÁ Michaela KRZYSCIK Mateusz HRISTOVA Kalina KROWARSCH Daniel TRANTÍRKOVÁ Silvie ZAKRZEWSKA Malgorzata TRANTÍREK Lukáš KREJČÍ Pavel

  Article in Periodical

  MOLECULAR THERAPY-NUCLEIC ACIDS, year: 2025, volume: 36, edition: 1, DOI

2024

• Achondroplasia: aligning mouse model with human clinical studies shows crucial importance of immediate postnatal start of the therapy

  RICO LLANOS Gustavo SPOUTIL Frantisek BLAHOVÁ Eva KOUDELKA Adolf PROCHAZKOVA Michaela CZYREK Aleksandra Anna FAFÍLEK Bohumil PROCHAZKA Jan GONZÁLEZ LÓPEZ Marcos KŘIVÁNEK Jan SEDLACEK Radislav KRAKOW Deborah NONAKA Yosuke NAKAMURA Yoshikazu KREJČÍ Pavel

  Article in Periodical

  Journal of bone and mineral research, year: 2024, volume: 39, edition: 12, DOI

• Discovery of Two Highly Selective Structurally Orthogonal Chemical Probes for Activin Receptor-like Kinases 1 and 2

  NĚMEC Václav REMEŠ Marek BEŇOVSKÝ Petr BÖCK Michael Christopher ŠRANKOVÁ Eliška WONG Jong Fu JULIEN Cros WILLIAMS Eleanor TSE Lap Hang SMIL David ENSAN Deeba ISAAC Methvin B AL-AWAR Rima GOMOLKOVÁ Regína URSACHI Vlad-Constantin FAFÍLEK Bohumil KAHOUNOVA Zuzana VICHOVA Rachel VACEK Ondrej BERGER Benedict-Tilman WELLS Carrow I CORONA Cesear R VASTA James D ROBERS Matthew B KREJČÍ Pavel SOUČEK Karel BULLOCK Alex N KNAPP Stefan PARUCH Kamil

  Article in Periodical

  Journal of Medicinal Chemistry, year: 2024, volume: 67, edition: 15, DOI

• Ligand bias underlies differential signaling of multiple FGFs via FGFR1

  KARL Kelly NUALA Del Piccolo LIGHT Taylor ROY Tanaya DUDEJA Pooja URSACHI Vlad-Constantin FAFÍLEK Bohumil KREJČÍ Pavel HRISTOVA Kalina

  Article in Periodical

  elife, year: 2024, volume: 12, edition: April 2024, DOI

2022

• 4-PBA Treatment Improves Bone Phenotypes in the Aga2 Mouse Model of Osteogenesis Imperfecta

  DURAN I. ZIEBA J. CSUKASI F. MARTIN J. H. WACHTELL D. BARAD M. DAWSON B. FAFÍLEK Bohumil JACOBSEN C. M. AMBROSE C. G. COHN D. H. KREJČÍ Pavel LEE B. H. KRAKOW D.

  Article in Periodical

  Journal of bone and mineral research, year: 2022, volume: 37, edition: 4, DOI

• Expanding horizons of achondroplasia treatment: current options and future developments

  FAFÍLEK Bohumil BOSÁKOVÁ Michaela KREJČÍ Pavel

  Article in Periodical

  Osteoarthritis and Cartilage, year: 2022, volume: 30, edition: 4, DOI

• LuminoCell: a versatile and affordable platform for real-time monitoring of luciferase-based reporters

  WEISSOVÁ Kamila FAFÍLEK Bohumil RADASZKIEWICZ Tomasz Witold ÇELIKER Canan MACHÁČKOVÁ Petra ČECHOVÁ Tamara ŠEBESTÍKOVÁ Jana HAMPL Aleš BRYJA Vítězslav KREJČÍ Pavel BÁRTA Tomáš

  Article in Periodical

  Life science alliance, year: 2022, volume: 5, edition: 8, DOI

2021

• An RNA aptamer restores defective bone growth in FGFR3-related skeletal dysplasia in mice

  KIMURA T. BOSÁKOVÁ Michaela NONAKA Y. HRUBA Eva YASUDA K. FUTAKAWA S. KUBOTA T. FAFÍLEK Bohumil GREGOR Tomáš POOVAKULATHU ABRAHAM Sara GOMOLKOVÁ Regína BELASKOVA Silvie PEŠL Martin CSUKASI F. DURAN I. FUJIWARA M. KAVKOVA Michaela ZIKMUND Tomas KAISER Josef BUCHTOVÁ Marcela KRAKOW D. NAKAMURA Y. OZONO K. KREJČÍ Pavel

  Article in Periodical

  Science Translational Medicine, year: 2021, volume: 13, edition: 592, DOI

2020

• Elucidation of protein interactions necessary for the maintenance of the BCR-ABL signaling complex

  GREGOR Tomáš BOSÁKOVÁ Michaela NITĂ Alexandru POOVAKULATHU ABRAHAM Sara FAFÍLEK Bohumil ČERNOHORSKÁ Nicole RYNEŠ Jan TRANTÍRKOVÁ Silvie ŽÁČKOVÁ Daniela MAYER Jiří TRANTÍREK Lukáš KREJČÍ Pavel

  Article in Periodical

  Cellular and molecular life sciences, year: 2020, volume: 77, edition: 19, DOI