Mgr. Bohumil Fafílek, Ph.D.

2019

• Fibroblast growth factor receptor influences primary cilium length through an interaction with intestinal cell kinase

  BOSÁKOVÁ Michaela NITĂ Alexandru GREGOR Tomáš VAŘECHA Miroslav GUDERNOVÁ Iva FAFÍLEK Bohumil BÁRTA Tomáš BASHEER Neha POOVAKULATHU ABRAHAM Sara BÁLEK Lukáš TOMANOVÁ Markéta FIALOVÁ KUČEROVÁ Jana BOSÁK Juraj POTĚŠIL David ZIEBA Jennifer SONG Jieun KONIK Peter PARK Sohyun DURAN Ivan ZDRÁHAL Zbyněk ŠMAJS David JANSEN Gert FU Zheng KO Hyuk Wan HAMPL Aleš TRANTÍREK Lukáš KRAKOW Deborah KREJČÍ Pavel

  Article in Periodical

  Proceedings of the National Academy of Sciences of the United States of America, year: 2019, volume: 116, edition: 10, DOI

2018

• The inositol phosphatase SHIP2 enables sustained ERK activation downstream of FGF receptors by recruiting Src kinases

  FAFÍLEK Bohumil BÁLEK Lukáš BOSÁKOVÁ Michaela VAŘECHA Miroslav NITĂ Alexandru GREGOR Tomáš GUDERNOVÁ Iva KŘENOVÁ Jitka GHOSH S. PISKÁČEK Martin JONATOVA Lucie ČERNOHORSKÁ Nicole ZIEBA J.T. KOSTAS M. HAUGSTEN E.M. WESCHE J. ERNEUX C. TRANTÍREK Lukáš KRAKOW D. KREJČÍ Pavel

  Article in Periodical

  SCIENCE SIGNALING, year: 2018, volume: 11, edition: 548, DOI

2017

• Inhibitor repurposing reveals ALK, LTK, FGFR, RET and TRK kinases as the targets of AZD1480

  GUDERNOVÁ Iva BÁLEK Lukáš VAŘECHA Miroslav FIALOVÁ KUČEROVÁ Jana BOSÁKOVÁ Michaela FAFÍLEK Bohumil PALUŠOVÁ Veronika ULDRIJAN Stjepan TRANTÍREK Lukáš KREJČÍ Pavel

  Article in Periodical

  Oncotarget, year: 2017, volume: 8, edition: 65, DOI

• One reporter for in-cell activity profiling of majority of protein kinase oncogenes

  GUDERNOVÁ Iva TRANTÍRKOVÁ Silvie EL GHANNAMOVÁ Barbora FAFÍLEK Bohumil VAŘECHA Miroslav BÁLEK Lukáš HRUBÁ Eva JONÁTOVÁ Lucie JELÍNKOVÁ Iva BOSÁKOVÁ Michaela TRANTÍREK Lukáš MAYER Jiří KREJČÍ Pavel

  Article in Periodical

  eLife, year: 2017, volume: 6, edition: "e21536", DOI

• Statins do not inhibit the FGFR signaling in chondrocytes

  FAFÍLEK Bohumil HAMPL Marek ŘIČÁNKOVÁ Nikola VESELA I. BÁLEK Lukáš BOSÁKOVÁ Michaela GUDERNOVÁ Iva VAŘECHA Miroslav BUCHTOVÁ marcela KREJČÍ Pavel

  Article in Periodical

  Osteoarthritis and Cartilage, year: 2017, volume: 25, edition: 9, DOI

2016

• Wnt Signaling Inhibition Deprives Small Intestinal Stem Cells of Clonogenic Capacity

  JANECKOVA L FAFÍLEK Bohumil KRAUSOVA M HORAZNA M VOJTECHOVA M ALBERICH-JORDA M SLONCOVA E GALUSKOVA K SEDLACEK R ANDEROVA M KORINEK V

  Article in Periodical

  GENESIS, year: 2016, volume: 54, edition: 3, DOI

2015

• HIC1 Tumor Suppressor Loss Potentiates TLR2/NF-kappa B Signaling and Promotes Tissue Damage-Associated Tumorigenesis

  JANECKOVA L POSPÍCHALOVÁ Vendula FAFÍLEK Bohumil VOJTECHOVA M TURECKOVA J DOBES J DUBUISSEZ M LEPRINCE D BALOGHOVA N HORAZNA M HLAVATA A STANCIKOVA J SLONCOVA E GALUSKOVA K STRNAD H KORINEK V

  Article in Periodical

  MOLECULAR CANCER RESEARCH, year: 2015, volume: 13, edition: 7, DOI

• NKD1 marks intestinal and liver tumors linked to aberrant Wnt signaling

  STANCIKOVA J KRAUSOVA M KOLAR M FAFÍLEK Bohumil SVEC J SEDLACEK R NEROLDOVA M DOBES J HORAZNA M JANECKOVA L VOJTECHOVA M OLIVERIUS M JIRSA Milan KORINEK V

  Article in Periodical

  Cellular Signalling, year: 2015, volume: 27, edition: 2, DOI

2013

• Expression of the chicken GDNF family receptor alpha-1 as a marker of spermatogonial stem cells

  MUCKSOVA J KALINA J BAKST M YAN H BRILLARD JP BENESOVA B FAFÍLEK Bohumil HEJNAR J TREFIL P

  Article in Periodical

  ANIMAL REPRODUCTION SCIENCE, year: 2013, volume: 142, edition: 1-2, DOI

• Troy, a Tumor Necrosis Factor Receptor Family Member, Interacts With Lgr5 to Inhibit Wnt Signaling in Intestinal Stem Cells

  FAFÍLEK Bohumil KRAUSOVA M VOJTECHOVA M POSPÍCHALOVÁ Vendula TUMOVA L SLONCOVA E HURANOVA M STANCIKOVA J HLAVATA A SVEC J SEDLACEK R LUKSAN O OLIVERIUS M VOSKA Ivan JIRSA Milan PACES J KOLAR M KRIVJANSKA M KLIMESOVA K TLASKALOVA-HOGENOVA H KORINEK V

  Article in Periodical

  Gastroenterology, year: 2013, volume: 144, edition: 2, DOI