Mgr. Lenka Dostálová

2024

• A novel thrombocytopenia-4-causing CYCS gene variant decreases caspase activity: Three-generation study

  ŠTIKA Jiří PEŠOVÁ Michaela STAŇO KOZUBÍK Kateřina SKALNÍKOVÁ Magdalena DOSTÁLOVÁ Lenka LOJA Tomas RADOVÁ Lenka PALUŠOVÁ Veronika RÉBLOVÁ Kamila VRZALOVÁ Zuzana BLAHÁKOVÁ Ivona TRIZULJAK Jakub ULDRIJAN Stjepan BLATNÝ Jan ŠMÍDA Michal POSPÍŠILOVÁ Šárka DOUBEK Michael

  Article in Periodical

  British journal of haematology, year: 2024, DOI

2023

• CRISPR/Cas9 technology as a useful tool in the study of chornic lymphocytic leukemia.

  PESCHELOVÁ Helena MANČÍKOVÁ Veronika DOSTÁLOVÁ Lenka LADUNGOVÁ Adriana ŠKRNOVÁ Dominika HEJRET Václav ŠMÍDA Michal

  Conference abstract

  Year: 2023, type: Conference abstract

• CRISPR/Cas9 technology as a useful tool in the study of chronic lymphocytic leukemia.

  PESCHELOVÁ Helena KOZLOVÁ Veronika MANČÍKOVÁ Veronika DOSTÁLOVÁ Lenka LADUNGOVÁ Adriana ŠKRNOVÁ Dominika HEJRET Václav ŠMÍDA Michal

  Conference abstract

  Year: 2023, type: Conference abstract

• Exploring the mechanisms of Venetoclax resistence via drug screening and genome-wide CRISPR screening.

  LADUNGOVÁ Adriana PESCHELOVÁ Helena DOSTÁLOVÁ Lenka LODHI Yusuf GOTTUMUKKALA Narendra Varma MAYER Jiří ŠMÍDA Michal

  Conference abstract

  Year: 2023, type: Conference abstract

• Funkční efekt nově identifikované varianty v genu CYCS u rodiny s trombocytopenií typu 4.

  ŠTIKA Jiří VRZALOVÁ Zuzana STAŇO KOZUBÍK Kateřina PEŠOVÁ Michaela PALUŠOVÁ Veronika DOSTÁLOVÁ Lenka BLAHÁKOVÁ Ivona RADOVÁ Lenka ŠMÍDA Michal POSPÍŠILOVÁ Šárka DOUBEK Michael

  Conference abstract

  Year: 2023, type: Conference abstract

• Genome-wide CRISPR/Cas9 knockout screening revealed genes involved in CD20 regulation in rituximab-resistant cells.

  DOSTÁLOVÁ Lenka LEDEREROVÁ Aneta PESCHELOVÁ Helena LOJA Tomáš ŠMÍDA Michal

  Conference abstract

  Year: 2023, type: Conference abstract

• Genome-wide CRISPR/Cas9 knockout screening revealed genes involved in CD20 regulation.

  DOSTÁLOVÁ Lenka LEDEREROVÁ Aneta PESCHELOVÁ Helena LOJA Tomáš ŠMÍDA Michal

  Conference abstract

  Year: 2023, type: Conference abstract

• Chasing the epigenetic landscape to enhance CAR-T cell activity py preventing CD19 antigen escape in relapsed models.

  GOTTUMUKKALA Narendra Varma LEDEREROVÁ Aneta DOSTÁLOVÁ Lenka LADUNGOVÁ Adriana LODHI Yusuf ŠMÍDA Michal

  Conference abstract

  Year: 2023, type: Conference abstract

• Identification of novel targets that upregulate CD20 expression in rituximab-resistant cells with the use of genomewide CRISPR screening.

  DOSTÁLOVÁ Lenka LEDEREROVÁ Aneta PESCHELOVÁ Helena LOJA Tomáš ŠMÍDA Michal

  Conference abstract

  Year: 2023, type: Conference abstract

• Nově identifikovaná varianta v genu CYCS u rodiny s trombocytopenií typu 4 a její funkční dopad.

  ŠTIKA Jiří VRZALOVÁ Zuzana STAŇO KOZUBÍK Kateřina PEŠOVÁ Michaela PALUŠOVÁ Veronika DOSTÁLOVÁ Lenka BLAHÁKOVÁ Ivona RADOVÁ Lenka ŠMÍDA Michal POSPÍŠILOVÁ Šárka DOUBEK Michael

  Conference abstract

  Year: 2023, type: Conference abstract