Project information
Quantitative analysis of effect of tubular system on electrical activity of cardiac cells
- Project Identification
- GP204/02/D129
- Project Period
- 9/2002 - 8/2004
- Investor / Pogramme / Project type
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Czech Science Foundation
- Postdoctoral projects
- MU Faculty or unit
- Faculty of Medicine
The project is a contribution to the solution of one of the major problems of cellular biophysics of electrical phenomena in cardiac cells. As follows from recent experimental work in cardiac ventricular cells, ionic channels are distributed differently between the fine transverse-axial tubular system (TAT-system) and the peripheral membrane. In addition, the accumulation and/or depletion of ions in the TAT- system (during trains of excitations) may significantly affect the excitation-contraction coupling in mammalian ventricular cells. However, quantitative models used for simulation of action potentials in cardiac cells so far did not include a description of electrical activity of the tubular membrane. The aim of this project is to supplement the present conception of quantitative models of ventricular action potentials with a quantitative description of electrical activity of tubular membrane. The design of TAT-system models includes systems of partial differential equations and simplified m
Publications
Total number of publications: 16
2005
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Effect of ajmaline on transient outward current Ito in rat ventricular myocytes
General Physiology and Biophysics, year: 2005, volume: 24, edition: 1
2004
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Action potential voltage clamp method used in analysis of rate-dependent changes of action potential
Analysis of Biomedical Signals and Images, year: 2004, volume: 17, edition: 1
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Concentration changes in Ca2+ and K+ in the t-tubules of rat and guinea pig as estimated in two models of ventricular myocytes
Year: 2004, type: Conference abstract
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Changes of [Ca2+] in the t-tubule lumen during activity may modulate the inotropic state of rat cardiac ventricular myocytes
Year: 2004, type: Conference abstract
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Ion concentration changes in transverse-axial tubular system of rat and guinea pig ventricular cardiomyocytes: a simulation study
Year: 2004, type: Conference abstract
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Ionic concentration changes in the tubular system of rat ventricular cardiac cell model
Engineering Mechanics 2004, year: 2004
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Physiological consequences of ionic concentration changes in cardiac cell tubular System
Biomechanics of Man, year: 2004
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Quantitative analysis of ionic concentration changes in tubular system of guinea pig ventricular cardiomyocyte
Analysis of Biomedical Signals and Images, year: 2004
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Quantitative modelling of interaction of propafenone with sodium channels in cardiac cells
Medical & Biological Engineering & Computing, year: 2004, volume: 42, edition: 2
2003
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A quantitative model of the cardiac ventricular cell incorporating the transverse-axial tubular system
General Physiology and Biophysics, year: 2003, volume: 22, edition: 3