Project information
Quantitative analysis of effect of tubular system on electrical activity of cardiac cells
- Project Identification
- GP204/02/D129
- Project Period
- 9/2002 - 8/2004
- Investor / Pogramme / Project type
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Czech Science Foundation
- Postdoctoral projects
- MU Faculty or unit
- Faculty of Medicine
The project is a contribution to the solution of one of the major problems of cellular biophysics of electrical phenomena in cardiac cells. As follows from recent experimental work in cardiac ventricular cells, ionic channels are distributed differently between the fine transverse-axial tubular system (TAT-system) and the peripheral membrane. In addition, the accumulation and/or depletion of ions in the TAT- system (during trains of excitations) may significantly affect the excitation-contraction coupling in mammalian ventricular cells. However, quantitative models used for simulation of action potentials in cardiac cells so far did not include a description of electrical activity of the tubular membrane. The aim of this project is to supplement the present conception of quantitative models of ventricular action potentials with a quantitative description of electrical activity of tubular membrane. The design of TAT-system models includes systems of partial differential equations and simplified m
Publications
Total number of publications: 16
2003
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Impact of T-tubules on electrical activity of cardiac cells evaluated in a quantitative model
Year: 2003, type: Conference abstract
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Quantitative modelling of effect of transverse - axial tubular system on electrical activity of cardiac cells: Development of model II.
Engineering mechanics 2003., year: 2003
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Rate dependent changes of action potential waveform in rat ventricular myocytes. Action potential voltage clamp experiments
Proceedings of symposium: Chronobiological analysis in pathophysiology of cardiovascular system, year: 2003
2002
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Arrhythmogenic effect of extracellular K-depletion is prevented by the transverse-axial tubular system in a ventricular cardiac cell model
Scripta Medica Fac.Med.Univ.Masaryk.Brun., year: 2002, volume: 75, edition: 4
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Role of TAT-system in cardiac excitability: investigation in a quantitative model of a ventricular cardiac cell
Year: 2002, type: Conference abstract
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The role of transverse-axial tubular system in ventricular cardiac cell arrhythmogenesis: A simulation study
Biomechanics of man 2002, year: 2002