Project information
Relationship between genetic variability of antioxidant system and late complications of diabetes mellitus
- Project Identification
- GP303/02/D127
- Project Period
- 9/2002 - 8/2004
- Investor / Pogramme / Project type
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Czech Science Foundation
- Postdoctoral projects
- MU Faculty or unit
- Faculty of Medicine
Development of the late diabetic complications is closely related to the duration and metabolic compensation of the disease. Nevertheless, a considerable interindividual variability in the development, progression and clinical extent of the late complications is observed among diabetics. Part of this variability could be ascribed to genetic factors. Considering the apparent role of glycoxidation in the pathogenesis of diabetic complications, genes encoding antioxidant enzymes modulating the overall level of oxidant stress seem to be logical candidates. Less functional variants decreasing antioxidant capacity could act pathologically during the long period of hyperglycemia-driven enhanced formation of reactive oxygen species in diabetes. The aim of the study is to examine possible associations between genetic polymorphisms in genes encoding antioxidant enzymes and other related substances (paraoxonase, NAD(P)H: quinon oxidoreductase, glyoxalase and HFE protein) and the extent of diabetic lat
Publications
Total number of publications: 14
2007
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Genetic risk factors for diabetic nephropathy on chromosomes 6p and 7q identified by the set-association approach
Diabetologia, year: 2007, volume: 50, edition: 5
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Nutrient-gene interactions in diabetes - advanced glycation end products (AGEs)
Year: 2007, type: Conference abstract
2005
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Association of the Cluster of Genetic Risk Factors in Loci Related to Glycoxidation with Diabetic Nephropathy in Type 2 Diabetes Mellitus
Year: 2005, type: Conference abstract
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Genetic variability in the RAGE gene: Possible implications for nutrigenetics, nutrigenomics and understanding the susceptibility to diabetic complications
Molecular Nutrition & Food Research, year: 2005, volume: 49, edition: 7
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Haplotype analysis of the RAGE gene: identification of a haplotype marker for diabetic nephropathy in type 2 diabetes mellitus
Nephrology Dialysis Transplantation, year: 2005, volume: 20, edition: 6
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Identifikace genetických rizikových faktor diabetické nefropatie u T2DM v genech pro EDN1, LTA, RAGE a NOS3 pomocí multilokusové analýzy
Diabetologie, metabolismus, endokrinologie, výživa, year: 2005, volume: 8, edition: suppl 1
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Molekulární patofyziologie pozdních komplikací diabetu mellitus - genetická predispozice k rozvoji diabetických komplikaci
Vnitřní lékařství, year: 2005, volume: 51, edition: 4
2004
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Mapování vazebné nerovnováhy SNP v RAGE a GLY1 genech a identifikace haplotypového markeru diabetické nefropatie u T2DM v České populaci
Diabetologie, metabolismus, endokrinologie, výživa, year: 2004, volume: 7, edition: 1 (suppl)
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Molekulární patofyziologie pozdních komplikací diabetu mellitus - hyperglykemií indukované změny
Vnitřní lékařství, year: 2004, volume: 50, edition: 10
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Multilocus approach to the identification of genetic risk factors for diabetic nephropathy in type 2 diabetes
Diabetologia, year: 2004, volume: 47, edition: Suppl 1