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Project information
Ionising radiation as a tool in the investigations of the cell nuclear structure and in the development of new techniques for ecology and medicine

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Project Identification
GA202/01/0197
Project Period
1/2001 - 1/2003
Investor / Pogramme / Project type
Czech Science Foundation
  • Standard Projects
MU Faculty or unit
Faculty of Informatics
Cooperating Organization
Institute of Biophysics
  • Responsible person doc. RNDr. Stanislav Kozubek, DrSc.
Institute of Nuclear Physics
  • Responsible person Ing. Václav Kroha , CSc.

Our recent observations on chromosomal exchange aberrations induced by fast neutrons in human lymphocytes suggest that the frequency of these exchanges between specific pairs of chromosomes is strikingly higher as compared with the expectation. We have found that this phenomenon is related to the specific structure of cell nuclei. Such structure is also responsible for the frequent incidence of some types of malignant diseases. Owing to these circumstances our findings are of great importance for several fields of science and also for practical usage. The main objective of this project will be further investigations of the radiation induced exchange aberrations between specific pairs of chromosomes with the goal to find their interaction probability. In parallel, structural studies will be performed and the results of both investigations will be compared. We have shown that the exchanges between some chromosome pairs can be easily detected using FISH. This finding can be exploited for more.

Publications

Total number of publications: 3

2002

2001

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