Structure of the human genome: Experimental results and models

• Authors: KOZUBEK Stanislav; LUKÁŠOVÁ Emilie; BÁRTOVÁ Eva; KOUTNÁ Irena; JIRSOVÁ Pavla; KOZUBEK Michal; GAŇOVÁ Alena; PASEKOVÁ Renata; AMRICHOVÁ Jana; FALK Martin; HLOŽEK Pavel
• Year of publication: 2002
• Type: Article in Proceedings
• Conference: Biophysics of the genome and its interactions
• MU Faculty or unit: Faculty of Informatics
• Field: Genetics and molecular biology
• Keywords: human genome structure; interphase cell nuclei
• Description: The higher-order chromatin structure is strikingly similar in various human cell types, although it may differ for some elements after differentiation. We conclude that the cell nucleus is an ordered and integrated structure, even though, substantially influenced by several sources of randomness.

Related projects

• How the study spatial order of specific genetic loci in nuclei of healthy and malignant tissues can contribute to the diagnostics and treatment of solid tumors.
• Development of new diagnostic teniques for oncology
• Investigation of the local control of gene expression using spectral microscopy and omage analysis techniques
• Epigenetic control of gene expression in malignant diseases
• Ionising radiation as a tool in the investigations of the cell nuclear structure and in the development of new techniques for ecology and medicine
• Application of computer image analysis in optical microscopy