Project information
Molecular basis of cell and tissue regulations
- Project Identification
- MSM0021622415
- Project Period
- 1/2005 - 12/2011
- Investor / Pogramme / Project type
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Ministry of Education, Youth and Sports of the CR
- Research Intents
- MU Faculty or unit
- Central European Institute of Technology
- Other MU Faculty/Unit
- Faculty of Medicine
- Keywords
- Cell; genomics; proteomics; biomedicine; gene expression; regulation mechanisms; chromatin structure; structure and interactions of biomolecules
The cell is a system in which each molecule is a component of interaction network. Due to the highly complex interconnection, function of cells and organisms is relatively resistant to failure of individual components of the network. Convergence of thought and methodical approaches which is characteristic for today’s postgenomic era, is a basis for interconnection of research capacities of molecular-biology oriented workgroups of the Masaryk University in the proposed Research Plan (RP). Solving of the RP will proceed in 4 program areas: 1. Regulation mechanisms in animal cells; 2. Functional domains of eukaryotic chromosomes; 3. Genomics and proteomics of regulation circuits in plants; 4. Functional analysis of the genome of clinically and biotechnologically important bacteria. The RP objective is to use approaches of structural biology, functional genomics, proteomics and bioinformatics to elucidate molecular basis of processes which are important from the viewpoint of perspective biomedical and biotechnology applications.
Publications
Total number of publications: 1208
2005
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Complexation between vanadium (V) and phenyllactate: Synthesis, spectral studies and crystal structure of (NEt4)(NH4)3[V2O2(O2)2(R-3-phlact)2][V2O2(O2)2(S-3-phlact)2].6H2O, [3-phlact = 3-phenyllactato(2-)]
Inorganica Chimica Acta, year: 2005, volume: 358, edition: 13
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CREB-binding protein sensitizes v-myb-transformed monoblasts to differentiation inducers
Functional Genomics and Disease, year: 2005
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Cytogenetic abnormalities in patients with multiple myeloma studied by FISH analysis: comparison of simultaneous immunofluorescent labelling of malignant plasma cells and immunomagnetically selected plasma cells
Year: 2005, type: Conference abstract
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Cytokinin induced photomorphogenesis in dark-grown Arabidopsis: a proteome analysis
Biologia plantarum, year: 2005
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Development of Arabidopsis and Tobacco Seedling Shoot Apical Meristem after ipt Transcriptional Activation in pOp/LhG4 System
Acta Biologica Cracoviensia, ser. Bot. 47 (Suppl.1), Abstracts XII International Conference on Plant Embryology, year: 2005
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Evidence of covalent interaction of fumaric acid esters with sulfhydryl groups in peptides
Journal of Mass Spectrometry, year: 2005, volume: 40, edition: 10
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Evolution of plant telomeres - step back or forward?
Year: 2005, type: Conference abstract
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Evolution of telomere synthesis in the plant order Asparagales
Year: 2005, type: R&D Presentation
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Expressional regulation of CKI1 provides molecular evidence for hormone interplay during Arabidopsis root development
Year: 2005, type: Conference abstract
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Functional analysis of p53 tumor suppressor in yeast
Differentiation, year: 2005, volume: 73, edition: 6