Project information
Functional analysis of the RAGE gene susceptibility haplotype and its role in the hyperglycemia-driven pathology
- Project Identification
- KJB501620601
- Project Period
- 2/2006 - 12/2008
- Investor / Pogramme / Project type
-
Academy of Sciences of the Czech Republic
- The research grant projects for juniors
- MU Faculty or unit
- Faculty of Medicine
- Keywords
- RAGE, haplotype, promotor, diabetes
Formation of Advanced Glycation End-products (AGEs) and subsequent activation of the Receptor of AGEs (RAGE) represents one of the principal pathogenic mechanisms of hyperglycaemia-induced cell damage.
Publications
Total number of publications: 15
2010
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Crohn's disease activity versus extent of DNA damage/repair and variability in the RAGE gene
Scripta Medica, year: 2010, volume: 83/2010, edition: 1
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Functional analysis of the common haplotype in the Receptor for Advanced Glycation End-products gene previously identified as a susceptibility factor for diabetic nephropathy
Experimental and Clinical Endocrinology & Diabetes, year: 2010, volume: 118, edition: 2
2008
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Diabetic threesome (hyperglycemia, renal function and nutrition) and advanced glycation end products: evidence for the multiple-hit agent?
Proceedings of the Nutrition Society, year: 2008, volume: 67, edition: 1
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Diabetická nefropatie- renální funkce a hladina sRAGE, genet. variabilita AGER genu
Year: 2008, type: Conference abstract
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Diabetická nefropatie, solubilní RAGE a genetická variabilita AGER genu
Year: 2008, type: Conference abstract
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Functional analysis of the susceptibility haplotype in the Receptor for Advanced Glycation End-products gene and its role in the hyperglycemia-driven pathology
Year: 2008, type: Conference abstract
-
Promotor and intron variants in the RAGE gene influence its transcriptional activity
Year: 2008, type: Conference abstract
-
RAGE gene variants and disease activity in young and adult patients with Crohn disease
Year: 2008, type: Conference abstract
-
Soluble RAGE, diabetic nephropathy and genetic variability in the AGER gene
Arch Physiol Biochem, year: 2008, volume: 114, edition: 2
2007
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Haplotype-based association study between the region of 6p chromosome spanning the AGER - TNFA - LTA - NFKBIL1 - BAT1 and diabetic nephropathy
Year: 2007, type: Conference abstract