Project information
Rozlišení a molekulární analýza aloreaktivních a nádorově-specifických T lymfocytů in vitro
- Project Identification
- 1A8709
- Project Period
- 8/2005 - 12/2009
- Investor / Pogramme / Project type
-
Ministry of Health of the CR
- Health of People (National Research Programme)
- MU Faculty or unit
-
Faculty of Medicine
- prof. MUDr. Jaroslav Michálek, Ph.D.
- Mgr. Darina Očadlíková, Ph.D.
- prof. MUDr. Jaroslav Štěrba, Ph.D.
- MUDr. Kateřina Toušovská, Ph.D.
- Keywords
- T lymfocyt
Náplní projektu je identifikace, rozlišení a molekulární analýza individuálních klonů T lymfocytů zodpovědných za rozvoj reakce štěpu proti hostiteli a reakce štěpu proti nádoru s cílem potlačení aloreaktivity a potenciace protinádorové reaktivity.
Publications
Total number of publications: 26
2011
-
Multifunctional immune-modulatory protein HLA-E identified on both tumor cells and background microenvironment cells in classical Hodkgin lymphoma: Clinical implications.
Year: 2011, type: Conference abstract
2010
-
Individual myeloma specific T-cell clones eliminate tumour cells and correlate with clinical outcomes in patients with multiple myeloma
British Journal of Haematology, year: 2010, volume: 148, edition: 6
2009
-
4th myeloma and 2nd immunotherapy workshop
Year: 2009, type: Workshop
-
Elimination of graft versus host reactivity and preservation of graft versus leukemia and graft versus myeloma effect using selective depletion of donor alloreactive T cells
Year: 2009, type: Conference abstract
-
Characterization of T cell receptor beta repertoire in T cell population associated with graft-versus-host and graft-versus-leukemia effect
Year: 2009, type: Conference abstract
-
In Vitro Activation of Cytotoxic T Lymphocytes By Muc1 Pulsed Dendritic Cells
The Open Cancer Immunology Journal, year: 2009, volume: 2, edition: 1
-
In vitro activation of cytotoxic T-lymphocytes by hTERT-pulsed dendritic cells
Journal of immunotoxicology, year: 2009, volume: 6, edition: 4
-
In vitro activation of myeloma-specific cytotoxic T cells by hTERT pulsed dendritic cells
Year: 2009, type: Conference abstract
-
In vitro activation of myeloma-specific cytotoxic T cells by MUC1 pulsed dendritic cells
Year: 2009, type: Conference abstract
-
Myeloma - specific T-cell clones can eliminate tumor cells and their long-term correlate with clinical outcomes in patients with multiple myeloma
Year: 2009, type: Conference abstract