Publication details
Individual myeloma specific T-cell clones eliminate tumour cells and correlate with clinical outcomes in patients with multiple myeloma
| Authors | |
|---|---|
| Year of publication | 2010 |
| Type | Article in Periodical |
| Magazine / Source | British Journal of Haematology |
| MU Faculty or unit | |
| Citation | MICHÁLEK, Jaroslav, Darina OČADLÍKOVÁ, Eva MATĚJKOVÁ, Veronika FOLTÁNKOVÁ, Silvie DUDOVÁ, Ondřej SLABÝ, Radek HORVÁTH, Luděk POUR and Roman HÁJEK. Individual myeloma specific T-cell clones eliminate tumour cells and correlate with clinical outcomes in patients with multiple myeloma. British Journal of Haematology. England: Wiley-Blackwell, 2010, vol. 148, No 6, p. 859-867. ISSN 0007-1048. |
| Field | Oncology and hematology |
| Keywords | multiple myeloma; T lymphocyte; clonality |
| Description | We developed an ex vivo strategy for inducing myeloma-specific cytotoxic T lymphocytes (CTLs) and demonstrate the possibility of identification and long-term in vivo monitoring of individual myeloma-specific T-cell clones using the most sensitive clonotypic assay that is able to detect low frequencies of T-cell clones (1 clonotypic cell in 10(6) cells). We conclude that the clonotypic assay is the most sensitive tool for immunomonitoring of low-frequency T cells. |
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