Project information
Bezpečná biotechnologie alotransplatovaných hematopoetických kmenových buněk u vybraných solidních a hematologických nádorů jako adoptivní imunoterapie
(NPVII11001)
- Project Identification
- 2B06058
- Project Period
- 7/2006 - 6/2011
- Investor / Pogramme / Project type
-
Ministry of Education, Youth and Sports of the CR
- Health and quality of life
- MU Faculty or unit
-
Faculty of Medicine
- prof. MUDr. Jaroslav Michálek, Ph.D.
- prof. MUDr. Roman Hájek, CSc.
- RNDr. Libor Hanák, Ph.D.
- RNDr. Radek Horváth, Ph.D.
- Dana Hrušková
- Mgr. Veronika Janečková, Ph.D.
- RNDr. Jiří Jelínek, Ph.D.
- RNDr. Eva Matějková
- Mgr. Klára Mollová
- Mgr. Lucie Říhová, Ph.D.
- Mgr. Jana Smejkalová, Ph.D.
- doc. RNDr. Sabina Ševčíková, Ph.D.
- Mgr. Hana Šváchová, Ph.D.
- Petra Vidláková
- Mgr. Kateřina Vopěnková, Ph.D.
- Cooperating Organization
-
Genex CZ, s.r.o.
Safe biotechnology of allotransplated hematopoietic stem cells in selected solid and haematologic tumors as an adoptive immunotherapy
The project focuses on the adoptive immunotherapy using experimental allogeneic hematopoietic stem cell transplantation. It primarily concentrates on finding a safe biotechnology of allogeneic stem cell graft preparation to minimize its unwanted alloreactivity leading often to lethal graft-versus-host reaction, and at the same time to preserve and potentiate its anti-tumor reactivity. Experimental verification of this procedure could lead to a rapid progress in the clinical usage of allogeneic transplantation in oncology and other fields.
Results
Publications
Total number of publications: 82
2009
-
Flow cytometric analysis of T regulatory cells in monoclonal gammopathy patients
Year: 2009, type: Conference abstract
-
Flow Cytometric Phenotyping and Analysis of T Regulatory Cells in Monoclonal Gammopathy Patients
Year: 2009, type: Conference abstract
-
Characterization of T cell receptor beta repertoire in T cell population associated with graft-versus-host and graft-versus-leukemia effect
Year: 2009, type: Conference abstract
-
Charakteristika čistých experimentálních výrobních prostor v podmínkách správné výrobní praxe.
Year: 2009, type: Conference abstract
-
Imunoterapie mnohočetného myelomu s využitím nádorového antigenu a dendritických buněk
Year: 2009, type: Conference abstract
-
Imunoterapie s využitím dendritických buněk u mnohočetného myelomu - průběžné výsledky klinické studie fáze II
Year: 2009, type: Conference abstract
-
In vitro activation of myeloma-specific cytotoxic T cells by hTERT pulsed dendritic cells
Year: 2009, type: Conference abstract
-
In vitro activation of myeloma-specific cytotoxic T cells by MUC1 pulsed dendritic cells
Year: 2009, type: Conference abstract
-
Molekulární identifikace alodepletovaných individuálních protinádorových klonů T lymfocytů
Year: 2009, type: Conference abstract
-
Myeloma - specific T-cell clones can eliminate tumor cells and their long-term correlate with clinical outcomes in patients with multiple myeloma
Year: 2009, type: Conference abstract