Project information
Determination of markers, screening and early diagnostics of cancer diseases using highly automated processing of multidimensional biomedical images
(Biomarker)
- Project Identification
- 2B06052
- Project Period
- 7/2006 - 6/2011
- Investor / Pogramme / Project type
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Ministry of Education, Youth and Sports of the CR
- Health and quality of life
- MU Faculty or unit
- Faculty of Informatics
- Keywords
- zpracování obrazu; optická mikroskopie; buněčné jádro; prostorové uspořádání; exprese genů; mikročipy; nádorová onemocnění; diagnostické markery
- Cooperating Organization
-
Brno University of Technology
- Responsible person doc. RNDr. Pavel Smrž, Ph.D.
- Responsible person Ing. Miloslav Richter, Ph.D.
The aim of the project is to develop new approaches to the processing of image data from fluorescence microscopy and microarrays that, in combination with the research in genomics and proteomics techniques, will help with the determination of markers, screening and early diagnostics of cancer diseases.
Results
Publications
Total number of publications: 121
2010
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Acquiarium: Free Software For Image Acquisition And Image Analysis In Cytometry
Year: 2010, type: Conference abstract
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AIFM2 (apoptosis-inducing factor, mitochondrion-associated, 2)
Atlas of Genetics and Cytogenetics in Oncology and Haematology, year: 2010, volume: 5, edition: 14, DOI
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Alteration in mitochondrial superoxide production by shRNA gene silencing of AIF in various cell line
Year: 2010, type: Conference abstract
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Alteration in mitochondrial superoxide production by shRNA gene silencing of AIF in various cell lines
Year: 2010, type: Conference abstract
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Application of reverse transcription PCR and capillary electrophoresis in the analysis of T-cell receptor beta variable repertoire
Advances in Molecular and Cancer Biology, 2010, year: 2010
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Automated spinning disk confocal microscopy in 3D live cell imaging
Year: 2010, type: Conference abstract
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CytoPacq: A web-based toolbox for simulation of 3D cell imaging and quality control of related image analysis
Year: 2010, type: Conference abstract
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Dasatinib Promotes BIM Dependent Apoptosis Via MEK/ERK without Need for Permanent BCR-ABL Inhibition
Year: 2010, type: Conference abstract
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Dasatinib suppresses MEK/ERK pathway activity without sustained BCR-ABL inhibition and promotes BIM dependent apoptosis in chronic myeloid leukaemia cells.
Year: 2010, type: Conference abstract
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Determination of pCrkL level in chronic myeloid leukaemia cells using flow cytometry
Advances in Molecular and Cancer Biology, 2010, year: 2010