Project information
Centre of Biophysical Chemistry, Bioelectrochemistry and Bioanalysis. New Tools for Genomics, Proteomics and Biomedicine
- Project Identification
- LC06035
- Project Period
- 3/2006 - 12/2011
- Investor / Pogramme / Project type
-
Ministry of Education, Youth and Sports of the CR
- Basic Research Center
- MU Faculty or unit
- Faculty of Science
- Keywords
- nukleové kyseliny, proteiny, karcinogeny, léčiva, poškození DNA, hybridizace DNA, interakce DNA-protein, nádorové supresory, amyloidní proteiny, mutantní proteiny, denaturace, agregace, elektrochemie, separace, kapilární elektroforéza, hmotová spektromet
- Cooperating Organization
-
Institute of Biophysics
Charles University
University of Pardubice
Masaryk Memorial Cancer Institute Brno
After completion of the human genome project, there is demand for simple and inexpensive methods enabling analysis of details of individuals' genomes. The contemporary world science is oriented towards utilization of electrochemical DNA detection in thisanalysis. DNA electroactivity was discovered at the Institute of Biophysics in Brno. Laboratories of this Institute belong to the world elite in this field for more than four decades. In the partner laboratories, a considerable progress has been attainedin the research of electrochemical DNA sensors as well as in analysis of proteins and other substances in recent years. This project is based on the existing results and it is oriented towards advanced studies of the properties of biomacromolecules andt heir interactions with surfaces, especially electrodes, and towards research of intermolecular interactions of DNA and/or proteins important in severe disorders (cancer, Parkinson's or Alzheimer's disease). On the basis of electrochemistry, miniaturiza
Publications
Total number of publications: 228
2017
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Self-assembled clusters of patchy rod-like molecules
SOFT MATTER, year: 2017, volume: 13, edition: 41, DOI
2013
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Luminescent Sensor for Carbonate Ion Based on Lanthanide (III) Complexes of 1,4,7,10-Tetraazacyclododecane-1, 4,7-Triacetic Acid (DO3A)
Journal of fluorescence, year: 2013, volume: 23, edition: 1, DOI
2012
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Analysis of renal stones by capillary isotachophoresis
Talanta, year: 2012, volume: 98, edition: August, DOI
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Mono(pyridine-N-oxide) analog of DOTA as a suitable organic reagent for a sensitive and selective fluorimetric determination of Ln(III) ions
Journal of Luminescence, year: 2012, volume: 132, edition: 8, DOI
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Nanotechnologies for society. New designs and applications of nanosensors and nanobiosensors in medicine and environmental analysis
International Journal of Nanotechnology, year: 2012, volume: 9, edition: 8-9, DOI
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Oxidation of 6-Benzylaminopurine-Copper(I) Complex on Pencil Graphite Electrode
Electroanalysis, year: 2012, volume: 24, edition: 4, DOI
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Potentiometric and Voltammetric Study of 6-Benzylaminopurine and Its Derivatives
Electroanalysis, year: 2012, volume: 24, edition: 2, DOI
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Tris(phosphonomethyl) Cyclen Derivatives: Synthesis, Acid-Base Properties and Complexation Studies with Cu2+ and Zn2+ Ions
Eur. J. Inorg. Chem., year: 2012, volume: 2012, edition: 15, DOI
2011
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A solution study of protonation chemical equlibria of nucleobases and short oligonucleotides
Year: 2011, type: Conference abstract
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A Study of Cytosine Oligonucleotides by Voltammetric and Spectral Methods
Year: 2011, type: Conference abstract