Project information
Centre of Biophysical Chemistry, Bioelectrochemistry and Bioanalysis. New Tools for Genomics, Proteomics and Biomedicine
- Project Identification
- LC06035
- Project Period
- 3/2006 - 12/2011
- Investor / Pogramme / Project type
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Ministry of Education, Youth and Sports of the CR
- Basic Research Center
- MU Faculty or unit
- Faculty of Science
- Keywords
- nukleové kyseliny, proteiny, karcinogeny, léčiva, poškození DNA, hybridizace DNA, interakce DNA-protein, nádorové supresory, amyloidní proteiny, mutantní proteiny, denaturace, agregace, elektrochemie, separace, kapilární elektroforéza, hmotová spektromet
- Cooperating Organization
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Institute of Biophysics
Charles University
University of Pardubice
Masaryk Memorial Cancer Institute Brno
After completion of the human genome project, there is demand for simple and inexpensive methods enabling analysis of details of individuals' genomes. The contemporary world science is oriented towards utilization of electrochemical DNA detection in thisanalysis. DNA electroactivity was discovered at the Institute of Biophysics in Brno. Laboratories of this Institute belong to the world elite in this field for more than four decades. In the partner laboratories, a considerable progress has been attainedin the research of electrochemical DNA sensors as well as in analysis of proteins and other substances in recent years. This project is based on the existing results and it is oriented towards advanced studies of the properties of biomacromolecules andt heir interactions with surfaces, especially electrodes, and towards research of intermolecular interactions of DNA and/or proteins important in severe disorders (cancer, Parkinson's or Alzheimer's disease). On the basis of electrochemistry, miniaturiza
Publications
Total number of publications: 228
2010
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Carbonate sensor based on macrocyclic DO3A ligand
Abstract book of XIV. International Symposium on Luminescence Spectrometry, year: 2010
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CITP analysis of aminopolycarboxylic acids
10th Workshop of Physical Chemists and Electrochemists, year: 2010
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COMPLEXES OF GLUTATHIONE WITH HEAVY METAL IONS AS A NEW BIOCHEMICAL MARKER OF AQUATIC ENVIRONMENT POLLUTION
ENVIRONMENTAL TOXICOLOGY AND CHEMISTRY, year: 2010, volume: 29/2010, edition: 3
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Determination of fluorides and phosphates by electromigration technique
Abstract Book of 10th Workshop of Physical Chemists and Electrochemists, year: 2010
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Development of anion sensors systems based on 4-(2-Pyridylazo)resorcinol (PAR)
Sborník 14. česko - slovenské spektroskopické konference, year: 2010
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Development of halide sensor based on 4-(2-Pyridylazo)resorcinol (PAR)
Year: 2010, type: Conference abstract
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Direct laser desorption ionisation time of flight TOF mass spectrometry of soil organic matter for fast soil fingerprints
Chemistry and Ecology, year: 2010, volume: 26, edition: 4
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Discovery of Two-dimensional Condensation of Nucleic Acids Components at the Mercury Electrodes – 45 Years´History“
X. Pracovní setkání fyzikálních chemiků a elektrochemiků & IV. Letní elektrochemická škola. 23. - 25.6.2010, Brno. Sborník příspěvků., year: 2010
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EFFECT OF COPPER IONS ON VOLTAMMETRIC SIGNALS OF AMINOPURINES AT THE CARBON ELECTRODE
X. pracovní setkání fyzikálních chemiků a elektrochemiků - sborník příspěvků, year: 2010
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Electrochemical Analysis of Aminopurines at Graphite Electrodes – Effect of Copper Ions
Year: 2010, type: Conference abstract