Project information
Genetic variability of pentose phosphate pathway as a modulating factor of the onset and progression of diabetic nephropathy
- Project Identification
- NR9443
- Project Period
- 1/2007 - 12/2009
- Investor / Pogramme / Project type
-
Ministry of Health of the CR
- Ministry of Agriculture R&D Programme
- MU Faculty or unit
- Faculty of Medicine
- Keywords
- diabetes, complications, nephropathy, predisposition
The project aims to ptimise early diagnostics of diabetec nephropathy by means of genetic analysis of transketolase and transaldolase genes and to allow individualised follow-up of diabetecs and, even individualised therapeutic strategy.
Publications
Total number of publications: 22
2009
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HPLC Measurement of Thiamine and its Phosphorylated Forms in Whole Blood and Plasma: Thiamine Status Assessment
Year: 2009, type: Conference abstract
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Progression of diabetic nephropathy vs. cross-talk between genetic variability in the RAAS system and its pharmacologic blockade: Results of 7-years observational pharmacogenetic study
Year: 2009, type: Conference abstract
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Relationships between levels of methylated arginine (ADMA), genetic variability of the reninangiontensin system and diabetic kidney disease
Year: 2009, type: Conference abstract
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Thiamine levels and transketolase genetic variants as modifiers of progression of diabetic nephropathy
Year: 2009, type: Conference abstract
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Vztah mezi hladinami methylovaných argininů (ADMA a SDMA), genetickou variabilitou v reninangiotenzinovém systému a postižením ledvin u diabetes mellitus 2. typu
Year: 2009, type: Conference abstract
2008
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Diabetic threesome (hyperglycemia, renal function and nutrition) and advanced glycation end products: evidence for the multiple-hit agent?
Proceedings of the Nutrition Society, year: 2008, volume: 67, edition: 1
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Genetic variability in the pentose phosphate cycle enzymes as a treatment-independent modifier of hyperglycemia toxicity in diabetic nephropathy
Year: 2008, type: Conference abstract
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Polymorphism in the pentose phosphate cycle enzymes as a modifier of hyperglycemia toxicity in diabetic nephropathy
Year: 2008, type: Conference abstract
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Thiamine Status and Genetic Variability in the Pentose Phosphate Cycle Enzymes as Risk Factors for Diabetic Nephropathy
Year: 2008, type: Conference abstract
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Variabilita antioxidačních a reparačních enzymů a parametry oxidačního stresu a reparace DNA u diabetu mellitus
Year: 2008, type: Conference abstract