Project information
Environment - carcinogenesis - oncology
- Project Identification
- MSM 141100003
- Project Period
- 1/1999 - 1/2004
- Investor / Pogramme / Project type
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Ministry of Education, Youth and Sports of the CR
- Research Intents
- MU Faculty or unit
- Faculty of Medicine
- Keywords
- environmental pollutants; genotoxic agents; mechanisms of genomic and extragenomic carcinogenesis; predictive bioparameters ; optimization of oncological therapy
The aim of this multidisciplinary project is to contribute to the research of the mechanisms of carcinogenesis with a special interest devoted to reduction of risks from environmental pollutants and genotoxic effects of therapeutic agents. The investigation of effects of persistent organic pollutants and other genotoxic compounds on induction and development of malignant tumors. The special interest will be paid also to the process of extragenomic carcinogenesis. Biomathematical analysis of risks of genotoxicity in their real proportions, which couples the data from basic environmental reasearch, toxicology, experimental biology and clinical oncology. Multivariate mathematical analysis of oncological bioparameters directed mainly to prediction of the efficacy of treatment in different types of tumors and optimization of therapeutic regimens.
Publications
Total number of publications: 670
2002
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Assistance and Protection - One of the main pillars of the Chemical Weapons Convention: Czech Republic access to the Article X of the Convention
Perspectives: The Central European Review of International Affairs, year: 2002, volume: 18, edition: 1
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Assistance and Protection One of the main pillars of the Chemical Weapons Convention: Access of the Czech Republic to the Article X of the Convention.
NATO-RTA-SAS Panel Symposium on Defensive Aspects of Chemical and Biological Warfare, Delft 2002. Abstracts, year: 2002
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Banning chemical weapons forever
NGO Committee for Peace, year: 2002
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Bioindicative value of eco-physiological indices in routine evaluation of soils - a pilot monitoring study in the Czech Republic
Die Bodenkultur, year: 2002, volume: 53, edition: 2
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Biotransformation of some organic energetics and toxicity of products in aquatic environment
Chemické Listy, year: 2002, volume: 96(S), edition: 1
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Biotransformation of some organic energetics and toxicity of products in aquatic environment
2nd Meeting on Chemistry and Life, year: 2002
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Comparison of AhR and ER mediated activities of hydroxyderivatives of polychlorinated biphenyls detected in vitro with luciferase reporter gene techniques
Book of Abstracts - The 2nd PCB Workshop: Recent Advances in the Environmental Toxicology and Health Effects of PCBs Emphasis on the latest advances and the perspective of Central and Eastern Europe. Brno, CR, 07-11/05/2002, year: 2002
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Concomitant chemotherapy paclitaxel, carboplatin,etopposide and radiotherapy in the treatment of advanced non-small cell lung cancer
Lung Cancer, year: 2002, volume: 37, edition: Suppl.1
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Contribution of biostatistics to the standardized evaluation fo model dose-response curves in experimental ecotoxicology-software adris, version 1.00
SECOTOX 2002, Trends and Advances in Environmental Chemistry and Ecotoxicology,Book and Abstracts, year: 2002
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Critical Illness Polyneuromyopathy: Is It a Part of the Multiple organ Failure (a Neuromuscular Failure)?
Neurology, year: 2002, volume: 7, edition: 58