Project information
Molecular mechanisms of the cell proliferation and differentiation
- Project Identification
- GD204/08/H054
- Project Period
- 1/2008 - 12/2011
- Investor / Pogramme / Project type
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Czech Science Foundation
- Doctor grants
- MU Faculty or unit
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Faculty of Science
- prof. RNDr. Jan Šmarda, CSc.
- prof. RNDr. Jiří Fajkus, CSc.
- doc. RNDr. Lenka Fajkusová, CSc.
- doc. RNDr. Jan Hejátko, Ph.D.
- doc. Mgr. Ctirad Hofr, Ph.D.
- Mgr. Jakub Horák, Dr. rer. nat.
- RNDr. Lubomír Janda, Ph.D.
- doc. RNDr. Jaromír Marek, Ph.D.
- doc. Mgr. Jan Paleček, Dr. rer. nat.
- prof. RNDr. Jana Šmardová, CSc.
- prof. RNDr. Renata Veselská, Ph.D., M.Sc.
- Mgr. Pavlína Zatloukalová, Ph.D.
- prof. RNDr. Zbyněk Zdráhal, Dr.
- Other MU Faculty/Unit
- Faculty of Informatics
- Keywords
- regulation of cell proliferation and differentiation, genomics and proteomics, plant, animal and microbial models, bioinformatics
Plants and animals evolved significantly different strategies of regulation of the cell proliferation and differentiation. Identification and comparison of molecular mechanisms driving those different strategies in plants, animals and microorganisms might contribute to the identification of their common principles. The project is based on collaboration of laboratories involved in the study of the processes of the cell proliferation and differentiation in those different model organisms including human beings. Collaboration of the laboratories with expertise in (i) molecular plant physiology, (ii) molecular mechanisms maintaining the genome stability, (iii) proliferation, differentiation and programmed cell death of cancer cells and (iv) bioinformatics will result into a multidisciplinary, while still functional team that will guarantee successful solution of scheduled tasks. Participation of multiple, recently collaborating laboratories including Core lab will allow effective employment of high-throughput instrumentation in the planned genomics and proteomics approaches.
Publications
Total number of publications: 87
2009
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Expression profiling of neuroblastoma cell lines after combined treatment with all-trans retinoic acid and LOX/COX inhibitors
Genes and Cancer - 26th Meeting, year: 2009
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Growth/differentiation factor-15 inhibits differentiation into osteoclasts - A novel factor involved in control of osteoclast differentiation
Differentiation, year: 2009, volume: 78, edition: 4
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Characterization of a GM7 glioblastoma cell line showing CD133 positivity and both cytoplasmic and nuclear location of nestin
Oncology Reports, year: 2009, volume: 21, edition: 1
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IDENTIFICATION OF GENES PARTICIPATING IN THE REGULATION OF CKI1 EXPRESION USING FORWARD GENETIC APPROACH
Year: 2009, type: Conference abstract
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Identification of genes participating in the regulation of CKI1 expression using forward genetic approach
Year: 2009, type: Conference abstract
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Identifikace nestin/CD133 pozitivních buněk v solidních nádorech mesenchymálního původu
XXXIII. Brněnské onkologické dny - edukační sborník, year: 2009
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Interactions of the receiver domain in histidine kinase receptors with the AHP proteins
Year: 2009, type: Conference abstract
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Konce chromozomů u rostlinné čeledi Alliaceae
Bulletin České společnosti experimentální biologie rostlin a Fyziologické sekce Slovenské botanické společnosti, year: 2009
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LOX/COX inhibitors may potentiate the antineoplastic effect of retinoids: in vitro study in neuroblastoma and medulloblastoma cell lines.
Genes and Cancer - 26th Meeting, year: 2009
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LOX/COX inhibitors: possible way to potentiate the antineoplastic effect of retinoids in neuroblastoma and medulloblastoma cell lines.
International Journal of Mol. Medicine 24 (Sup. 1) - the 14th World Congress on Advances in Oncology and the 12th International Symposium on Molecular Medicine., year: 2009