Project information
Národní centrum lékařské genomiky
(NCLG)
- Project Identification
- LM2015091
- Project Period
- 1/2016 - 12/2019
- Investor / Pogramme / Project type
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Ministry of Education, Youth and Sports of the CR
- Large Infrastructures for Research, Development and Innovation
- MU Faculty or unit
- Central European Institute of Technology
- Cooperating Organization
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Charles University
- Responsible person doc. Ing. Stanislav Kmoch, CSc.
University Hospital Pilsen
University Hospital Prague - Motol
University Hospital Brno-Bohunice
General Teaching Hospital Praha
National Centre of Medical Genomics (NCMG) is the only research infrastructure in the Roadmap for Large Research, Development and Innovation Infrastructures of the Czech Republic focused on medical genomics. Its existence and support must be therefore one of national priorities. Local (national) genomic infrastructure is the only way how we can unite genomic experts, clinicians, scientist, patients and industry to study, identify and understand causes of individual and population specific diseases. Interdisciplinary collaboration will increase competitiveness of Czech biomedical science and our recent results clearly document, that this approach leads to significant discoveries (e.g. identification of causal genes and elucidation of molecular basis of > 20 human genetic diseases, leukemia, aspergillosis, inherited neurodegenerative and neuromuscular diseases, skin diseases and metabolics diseases), may attract foreign investigators to use the expertize and may have economic impact (new diagnostic products introduced on the market thanks to collaboration of MU and company Generi BioTech). Infrastructure is also important for education and training of new generation of scientists, computing specialists, bioinformaticians, statisticians, instrument operators, clinical genomicists and clinicians. All participating groups are involved in pregraduate and postgraduate education as well as in organization of specialised training programs and courses and organisation of workshops and symposia, e.g. Next-gen Sequencing Technologies and Applications organized in 2013 in Brno.
Publications
Total number of publications: 37
2024
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Sequence typing of Haemophilus ducreyi isolated from patients in the Namatanai region of Papua New Guinea: Infections by Class I and Class II strain types differ in ulcer duration and resurgence of infection after azithromycin treatment
PLOS Neglected Tropical Diseases, year: 2024, volume: 18, edition: 8, DOI
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The hare syphilis agent is related to, but distinct from, the treponeme causing rabbit syphilis
PLoS One, year: 2024, volume: 19, edition: 8, DOI
2023
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A gene copy number arms race in action: X,Y-chromosome transmission distortion across a species barrier
Evolution : international journal of organic evolution, year: 2023, volume: 77, edition: 6, DOI
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Palaeoproteomic and Genomic Analyses of Bronze Age Population from Unětice Culture, Moravia, Czech Republic
Year: 2023, type: Conference abstract
2022
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Gastrointestinal symbiont diversity in wild gorilla: A comparison of bacterial and strongylid communities across multiple localities
Molecular Ecology, year: 2022, volume: 31, edition: 15, DOI
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Pyocin-mediated antagonistic interactions in Pseudomonas spp. isolated in James Ross Island, Antarctica
ENVIRONMENTAL MICROBIOLOGY, year: 2022, volume: 24, edition: 3, DOI
2021
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Genomic arrays identify high-risk chronic lymphocytic leukemia with genomic complexity: a multicenter study
Haematologica, year: 2021, volume: 106, edition: 1, DOI
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NFAT signaling in human mesenchymal stromal cells affects extracellular matrix remodeling and antifungal immune responses
iSCIENCE, year: 2021, volume: 24, edition: 6, DOI
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Whole exome sequencing reveals NOTCH1 mutations in anaplastic large cell lymphoma and points to Notch both as a key pathway and a potential therapeutic target
haematologica, year: 2021, volume: 106, edition: 6, DOI
2020
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Description of Massilia rubra sp. nov., Massilia aquatica sp. nov., Massilia mucilaginosa sp. nov., Massilia frigida sp. nov., and one Massilia genomospecies isolated from Antarctic streams, lakes and regoliths
Systematic and Applied Microbiology, year: 2020, volume: 43, edition: 5, DOI