Informace o projektu
Národní centrum lékařské genomiky
(NCLG)
- Kód projektu
- LM2015091
- Období řešení
- 1/2016 - 12/2019
- Investor / Programový rámec / typ projektu
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Ministerstvo školství, mládeže a tělovýchovy ČR
- Velké infrastruktury pro výzkum, vývoj a inovace
- Fakulta / Pracoviště MU
- Středoevropský technologický institut
- Spolupracující organizace
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Univerzita Karlova
- Odpovědná osoba doc. Ing. Stanislav Kmoch, CSc.
Fakultní nemocnice Plzeň
Fakultní nemocnice v Motole
Fakultní nemocnice Brno
Všeobecná fakultní nemocnice v Praze - Praha 2
National Centre of Medical Genomics (NCMG) is the only research infrastructure in the Roadmap for Large Research, Development and Innovation Infrastructures of the Czech Republic focused on medical genomics. Its existence and support must be therefore one of national priorities. Local (national) genomic infrastructure is the only way how we can unite genomic experts, clinicians, scientist, patients and industry to study, identify and understand causes of individual and population specific diseases. Interdisciplinary collaboration will increase competitiveness of Czech biomedical science and our recent results clearly document, that this approach leads to significant discoveries (e.g. identification of causal genes and elucidation of molecular basis of > 20 human genetic diseases, leukemia, aspergillosis, inherited neurodegenerative and neuromuscular diseases, skin diseases and metabolics diseases), may attract foreign investigators to use the expertize and may have economic impact (new diagnostic products introduced on the market thanks to collaboration of MU and company Generi BioTech). Infrastructure is also important for education and training of new generation of scientists, computing specialists, bioinformaticians, statisticians, instrument operators, clinical genomicists and clinicians. All participating groups are involved in pregraduate and postgraduate education as well as in organization of specialised training programs and courses and organisation of workshops and symposia, e.g. Next-gen Sequencing Technologies and Applications organized in 2013 in Brno.
Publikace
Počet publikací: 37
2024
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Sequence typing of Haemophilus ducreyi isolated from patients in the Namatanai region of Papua New Guinea: Infections by Class I and Class II strain types differ in ulcer duration and resurgence of infection after azithromycin treatment
PLOS Neglected Tropical Diseases, rok: 2024, ročník: 18, vydání: 8, DOI
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The hare syphilis agent is related to, but distinct from, the treponeme causing rabbit syphilis
PLoS One, rok: 2024, ročník: 19, vydání: 8, DOI
2023
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A gene copy number arms race in action: X,Y-chromosome transmission distortion across a species barrier
Evolution : international journal of organic evolution, rok: 2023, ročník: 77, vydání: 6, DOI
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Palaeoproteomic and Genomic Analyses of Bronze Age Population from Unětice Culture, Moravia, Czech Republic
Rok: 2023, druh: Konferenční abstrakty
2022
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Gastrointestinal symbiont diversity in wild gorilla: A comparison of bacterial and strongylid communities across multiple localities
Molecular Ecology, rok: 2022, ročník: 31, vydání: 15, DOI
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Pyocin-mediated antagonistic interactions in Pseudomonas spp. isolated in James Ross Island, Antarctica
ENVIRONMENTAL MICROBIOLOGY, rok: 2022, ročník: 24, vydání: 3, DOI
2021
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Genomic arrays identify high-risk chronic lymphocytic leukemia with genomic complexity: a multicenter study
Haematologica, rok: 2021, ročník: 106, vydání: 1, DOI
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NFAT signaling in human mesenchymal stromal cells affects extracellular matrix remodeling and antifungal immune responses
iSCIENCE, rok: 2021, ročník: 24, vydání: 6, DOI
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Whole exome sequencing reveals NOTCH1 mutations in anaplastic large cell lymphoma and points to Notch both as a key pathway and a potential therapeutic target
haematologica, rok: 2021, ročník: 106, vydání: 6, DOI
2020
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Description of Massilia rubra sp. nov., Massilia aquatica sp. nov., Massilia mucilaginosa sp. nov., Massilia frigida sp. nov., and one Massilia genomospecies isolated from Antarctic streams, lakes and regoliths
Systematic and Applied Microbiology, rok: 2020, ročník: 43, vydání: 5, DOI