Project information
Czech Infrastructure for Integrative Structural Biology
(CIISB)
- Project Identification
- LM2015043
- Project Period
- 1/2016 - 12/2019
- Investor / Pogramme / Project type
-
Ministry of Education, Youth and Sports of the CR
- Large Infrastructures for Research, Development and Innovation
- MU Faculty or unit
-
Central European Institute of Technology
- prof. RNDr. Vladimír Sklenář, DrSc.
The Czech Infrastructure for Integrative Structural Biology (CIISB) is a distributed infrastructure of the core facilities and central laboratories of CEITEC (Central European Institute of Technology, Brno) and BIOCEV (Biotechnology and Biomedicine Centre, Vestec, Prague-West) providing expertise and access to technologies used for integrative approaches to structural analysis of biologically important cellular components and macromolecules - proteins, nucleic acids, and their complexes. CIISB, equipped with the cutting-edge technologies (total investments will exceed 750 mil. CZK by the end of 2015), will offer access to the equipment and expertise in the following fields: high-field NMR spectroscopy; high throughput crystallization of biological macromolecules; X-ray diffraction techniques; Bio-SAXS measurements; AFM imaging; characterization of proteins, nucleic acids and complexes by biophysical methods including microcalorimetry, dynamic light scattering, and surface plasmon resonance; high-end cryo-electron microscopy and tomography allowing studies of cellular structures, organelles, and biomacromolecular complexes by 3D imaging; protein expression in eukaryotic cells; high-end mass spectrometry characterization of biomacromolecules; determination of protein post-translational modifications; MS-based peptide mapping/sequencing; high throughput sequencing and proteomic services. CIISB infrastructure aims to provide a high quality open access services in provision of methods and techniques on a level of national and trans-national importance. CIISB as National Affiliated Center is a part of the ESFRI projects INSTRUCT.
Publications
Total number of publications: 251
2023
-
Aerosol-assisted sol–gel synthesis of mesoporous Ag–Ta–SiO2 catalysts for the direct upgrading of ethanol to butadiene
RSC Sustainability, year: 2023, volume: 1, edition: 3, DOI
2022
-
Airborne Preparation of Small Gold Nanoparticles Dispersed on Mesoporous Silica for the Catalytic Oxidation of Glycerol to Dihydroxyacetone
ACS Applied Nano Materials, year: 2022, volume: 5, edition: 12, DOI
2021
-
Acetylace 7-hydroxy skupiny dibenzocyklooktadienových lignanů zvyšuje inhibici P-glykoproteinu
Year: 2021, type: Conference abstract
-
In-Cell NMR Spectroscopy of Functional Riboswitch Aptamers in Eukaryotic Cells
Angewandte Chemie International Edition, year: 2021, volume: 60, edition: 2, DOI
-
One-pot synthesis of 1-aryl-2-amino alcohols from the corresponding amides or nitriles
Year: 2021, type: Appeared in Conference without Proceedings
-
Unexpected formation of 1-aryl-2-aminoalcohols during reductions of the corresponding amides and nitriles
Year: 2021, type: Appeared in Conference without Proceedings
2020
-
Conformational flexibility in amidophosphoesters: a CSD analysis completed with two new crystal structures of (C6H5O)2P(O)X [X = NHC7H13 and N(CH2C6H5)2]
Acta Crystallographica Section C: Structural Chemistry, year: 2020, volume: 76, edition: 1, DOI
-
Demonstration of electron diffraction from membrane protein crystals grown in a lipidic mesophase after lamella preparation by focused ion beam milling at cryogenic temperatures
Journal of Applied Crystallography, year: 2020, volume: 53, edition: DEC, DOI
-
Heterometallic 3d-4f {Co2Gd4} phosphonates: new members of the potential magnetic cooler family
New Journal of Chemistry, year: 2020, volume: 44, edition: 2, DOI
-
Mildly acidic aluminosilicate catalysts for stable performance in ethanol dehydration
Applied Catalysis B: Environmental, year: 2020, volume: 271, edition: August 2020, DOI