Project information
Czech Infrastructure for Integrative Structural Biology
(CIISB)
- Project Identification
- LM2015043
- Project Period
- 1/2016 - 12/2019
- Investor / Pogramme / Project type
-
Ministry of Education, Youth and Sports of the CR
- Large Infrastructures for Research, Development and Innovation
- MU Faculty or unit
-
Central European Institute of Technology
- prof. RNDr. Vladimír Sklenář, DrSc.
The Czech Infrastructure for Integrative Structural Biology (CIISB) is a distributed infrastructure of the core facilities and central laboratories of CEITEC (Central European Institute of Technology, Brno) and BIOCEV (Biotechnology and Biomedicine Centre, Vestec, Prague-West) providing expertise and access to technologies used for integrative approaches to structural analysis of biologically important cellular components and macromolecules - proteins, nucleic acids, and their complexes. CIISB, equipped with the cutting-edge technologies (total investments will exceed 750 mil. CZK by the end of 2015), will offer access to the equipment and expertise in the following fields: high-field NMR spectroscopy; high throughput crystallization of biological macromolecules; X-ray diffraction techniques; Bio-SAXS measurements; AFM imaging; characterization of proteins, nucleic acids and complexes by biophysical methods including microcalorimetry, dynamic light scattering, and surface plasmon resonance; high-end cryo-electron microscopy and tomography allowing studies of cellular structures, organelles, and biomacromolecular complexes by 3D imaging; protein expression in eukaryotic cells; high-end mass spectrometry characterization of biomacromolecules; determination of protein post-translational modifications; MS-based peptide mapping/sequencing; high throughput sequencing and proteomic services. CIISB infrastructure aims to provide a high quality open access services in provision of methods and techniques on a level of national and trans-national importance. CIISB as National Affiliated Center is a part of the ESFRI projects INSTRUCT.
Publications
Total number of publications: 253
2020
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Molecular mechanism of glioblastoma cell differentiation
Year: 2020, type: Conference abstract
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Molecularly imprinted polymers and capillary electrophoresis for sensing phytoestrogens in milk
Journal of Dairy Science, year: 2020, volume: 103, edition: 6, DOI
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One-pot method for the synthesis of 1-aryl-2-aminoalkanol derivatives from the corresponding amides or nitriles
RSC Advances, year: 2020, volume: 10, edition: 42, DOI
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Preparation of ultrafine fibrous uranium dioxide by electrospinning
Journal of Nuclear Materials, year: 2020, volume: 528, edition: JAN 2020, DOI
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Pseudomonas leptonychotis sp. nov., isolated from Weddell seals in Antarctica
International Journal of systematic and Evolutionary Microbiology, year: 2020, volume: 70, edition: 1, DOI
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Stereocontrolled Synthesis of (-)-Bactobolin A
Journal of the American Chemical Society, year: 2020, volume: 142, edition: 16, DOI
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Thermal properties of Ag@Ni core-shell nanoparticles
Computer Coupling of Phase Diagrams and Thermochemistry, year: 2020, volume: 69, edition: JUN 2020, DOI
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Transgelin Silencing Induces Different Processes in Different Breast Cancer Cell Lines
Proteomics, year: 2020, volume: 20, edition: 7, DOI
2019
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#CEITEC100 Alumni Day
Year: 2019, type: Popularization text
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#CEITEC100 Open Day
Year: 2019, type: Popularization text