Project information
European Human Biomonitoring Initiative
(HBM4EU)
- Project Identification
- 733032
- Project Period
- 1/2017 - 6/2022
- Investor / Pogramme / Project type
-
European Union
- Horizon 2020
- Health, demographic change and wellbeing (Societal Challenges)
- MU Faculty or unit
-
Faculty of Science
- prof. RNDr. Jana Klánová, Ph.D.
- Mgr. Ondřej Adamovský, Ph.D.
- Lola Murielle Bajard ép.Esner, Ph.D.
- prof. RNDr. Luděk Bláha, Ph.D.
- doc. RNDr. Pavel Čupr, Ph.D.
- Elena Dominguez Romero, PhD.
- Mgr. Klára Komprdová, Ph.D.
- Ing. Štěpán Koudelka, Ph.D.
- RNDr. Ondřej Májek, Ph.D.
- Lisa Emily Melymuk, Ph.D.
- Chander Kant Negi, Ph.D.
- Mgr. Ondřej Ngo, Ph.D.
- Ing. Šárka Palátová, Ph.D.
- Veronika Janina Schacht, Ph.D.
- Mgr. Libor Šulc, Ph.D.
- Jakub Vinkler, DiS.
- Chiara Maria Vitale, PhD
- Cooperating Organization
-
Institute of Experimental Medicine of the ASCR, v. v. i.
- Responsible person MUDr. Radim Šrám, DrSc.
- Responsible person prof. MUDr. Milena Králíčková, Ph.D.
- Responsible person prof. Ing. Jana Hajšlová, CSc.
- Responsible person Ing. Adéla Fraňková, Ph.D.
- Responsible person Gorazd B. Stokin
- Responsible person RNDr. Ondřej Májek, Ph.D.
- Responsible person Marike Kolossa-Gehring
The overarching goal of the European Human Biomonitoring Initiative is to generate knowledge to inform the safe management of chemicals and so protect human health. We will use human biomonitoring to understand human exposure to chemicals and resulting health impacts and will communicate with policy makers to ensure that our results are exploited in the design of new chemicals policies and the evaluation of existing measures.
Key objectives include:
- Harmonizing procedures for human biomonitoring across 26 countries, to provide policy makers with comparable data on human internal exposure to chemicals and mixtures of chemicals at EU level;
- Linking data on internal exposure to chemicals to aggregate external exposure and identifying exposure pathways and upstream sources. Information on exposure pathways is critical to the design of targeted policy measures to reduce exposure;
- Generating scientific evidence on the causal links between human exposure to chemicals and negative health outcomes; and
- Adapting chemical risk assessment methodologies to use human biomonitoring data and account for the contribution of multiple external exposure pathways to the total chemical body burden.
We will achieve these objectives by harmonizing human biomonitoring initiatives in 26 countries, drawing on existing expertise and building new capacities. By establishing National Hubs in each country to coordinate activities, we will create a robust Human Biomonitoring Platform at European level. This initiative contributes directly to the improvement of health and well-being for all age groups, by investigating how exposure to chemicals affects the health of different groups, such as children, pregnant women, foetuses and workers. We will also investigate how factor such as behavior, lifestyle and socio-economic status influence internal exposure to chemicals across the EU population. This knowledge will support policy action to reduce chemical exposure and protect
health.
Publications
Total number of publications: 51
2021
-
Flame Retardants-Mediated Interferon Signaling in the Pathogenesis of Nonalcoholic Fatty Liver Disease
International Journal of Molecular Sciences, year: 2021, volume: 22, edition: 8, DOI
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Towards harmonised criteria in quality assurance and quality control of suspect and non-target LC-HRMS analytical workflows for screening of emerging contaminants in human biomonitoring
TrAC Trends in Analytical Chemistry, year: 2021, volume: 136, edition: March 2021, DOI
2020
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Dietary Intake of Acrylamide and Risk of Breast, Endometrial, and Ovarian Cancers: A Systematic Review and Dose-Response Meta-analysis
Cancer Epidemiology, Biomarkers & Prevention, year: 2020, volume: 29, edition: 6, DOI
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Suspect and non-targeted screening of chemicals of emerging concern for human biomonitoring, environmental health studies and support to risk assessment: From promises to challenges and harmonisation issues
Environment International, year: 2020, volume: 139, edition: June 2020, DOI
2019
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A review of phthalate pharmacokinetics in human and rat: what factors drive phthalate distribution and partitioning?
Drug metabolism Reviews, year: 2019, volume: 51, edition: 3, DOI
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Environmental ototoxicants, a potential new class of chemical stressors
Environmental Research, year: 2019, volume: 171, edition: April, DOI
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Isomers of photo-unstable compounds should be evaluated as the individual substances due to their potential different exposure effects
Year: 2019, type: Article in Periodical (without peer review)
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Linking past uses of legacy SVOCs with today's indoor levels and human exposure
Environment International, year: 2019, volume: 127, edition: June, DOI
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Physiology-based toxicokinetic modelling in the frame of the European Human Biomonitoring Initiative
Environmental Research, year: 2019, volume: 172, edition: May, DOI
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Prioritization of hazards of novel flame retardants using the mechanistic toxicology information from ToxCast and Adverse Outcome Pathways
Environmental Sciences Europe, year: 2019, volume: 31, edition: February, DOI