Project information
Telomere dynamics in selected types of solid malignant diseases
- Project Identification
- GA301/99/0045
- Project Period
- 1/1999 - 1/2001
- Investor / Pogramme / Project type
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Czech Science Foundation
- Standard Projects
- MU Faculty or unit
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Faculty of Science
- Cooperating Organization
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Institute of Biophysics
- Responsible person prof. RNDr. Jiří Fajkus, CSc.
- Responsible person doc. RNDr. Lenka Fajkusová, CSc.
- Responsible person prof. MUDr. Rostislav Vyzula, CSc.
Telomerase, a nucleoprotein enzyme complex, plays a crucial role in the development of cellular immortality and carcinogenesis. The project is focused on using activity and expression of telomerase in molecular diagnostics of cancer. The work on the pro ject will result in providing data on telomere dynamics in cancer tissue samples, as well as in optimising diagnostic methods and their introduction in oncolgy practice.
Publications
Total number of publications: 22
2006
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Comparison of electromigration properties of stained microbial strains, cultured and from body fluids, in capillary electrophoreis
20th Internat. Symposium on Microscale Bioseparations, MSB 2006, year: 2006
2003
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The evaluation of left ventricular function in childhood cancer survivors by pharmacological stress echocardiography
Neoplasma, year: 2003, volume: 50, edition: 3
2002
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Tiptoeing to chromosome tips: facts, promises and perils of today's human telomere biology
Phil. Trans. R. Soc. Lond. B, year: 2002, volume: roč. 357, edition: April
2001
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Columnar Structure Of Telomeric Chromatin
Journal of Biomolecular Structure and Dynamics, year: 2001
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COLUMNAR STRUCTURE OF TELOMERIC CHROMATIN
Role of Telomeres and Telomerase in Cancer and Aging, year: 2001
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Early diagnosis and treatment of mycotic infection by PCR
Scripta Medica, year: 2001, volume: 74, edition: 3
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Further characterization of telomeric chromatin
Aktuální témata z buněčné a molekulární biologie, year: 2001
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HODNOCENÍ TELOMERÁZOVÉ AKTIVITY A DÉLKY TELOMER U MNOHOČETNÉHO MYELOMU
XV.OLOMOUCKÉ HEMATOLOGICKÉ DNY S MEZINÁRODNÍ ÚČASTÍ, year: 2001
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In Situ Analysis of Telomeres in Haematological Malignancies
European Journal of Human Genetics, year: 2001
2000
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Detailed Mapping of Methylcythosine Positions at the CpG Island Surrounding tha Pa Promoter at the bcr-abl Locus in CML Patients in Two Cell Lines, K562 and BV 173
Blood Cells, Molecules and Diseases, year: 2000, volume: 26, edition: 3