Publication details
Changes in the expression of FGFR3 in patients with chronic myeloid leukaemia receiving transplants of allogeneic peripheral blood stem cells
| Authors | |
|---|---|
| Year of publication | 2001 |
| Type | Article in Periodical |
| Magazine / Source | British Journal of Haematology |
| MU Faculty or unit | |
| Citation | |
| Field | Oncology and hematology |
| Keywords | fibroblast growth factor receptor 3; chronic myeloid leukaemia; stem cell transplantation; BCR/ABL; prognosis |
| Description | Patients suffering from CML express high levels of FGFR3 mRNA in white blood cells (WBCs). After stem cell transplantation and reconstitution of haematopoiesis, the expression of FGFR3 decreased and was maintained at low levels that are typical of healthy individuals. FGFR3 expression became upregulated again in patients that had accelerated BCR/ABL rearrangement and underwent relapse of leukaemia. |
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