Project information
Bioavailability and mechanism of antioxidant activity of phenolic acids and lignans
- Project Identification
- GA303/00/D062
- Project Period
- 1/2000 - 1/2003
- Investor / Pogramme / Project type
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Czech Science Foundation
- Standard Projects
- MU Faculty or unit
- Faculty of Medicine
Recent epidemiological data support a protective effect of intake of vegetables and fruits against cancer and cardiovascular diseases. The protective effect is also attributed to antioxidant polyphenolic compounds, such as flavonoids, found in the plants in the high amounts. Polyphenols show a strong antioxidant activity in vitro, but little is known about their bioavailability. The former purpose of this project is to determine the bioavailability and the mechanism of antioxidative effect of dicoffeoyl quinic acids and flavonoids present in the artichoke extract. The interest in dicaffeoylquinic acids has expanded rapidly in the last years due to their anti-HIV and HIV-integrase inhibition activity. The antioxidant activity of caffeoylquinic acids can be mediated by the potent antiradical activity and/or by forming chelates with ferric ions, that cannot produce reactive oxygen species. The letter purpose of this project is to discover the mechanism of antioxidative effect of dibenzocyclooctadiene lign
Publications
Total number of publications: 34
2001
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Flavonoidní látky v kořeni Šišáku bajkalského (Scutellaria baicalensis Georgi)- analýza, antioxidační vlastnosti, potenciální využití v potravinářství.
Biologicky aktivní fenolické látky, year: 2001
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MASS SPECTROMETRY OF 1,3- AND 1,5-DICAFFEOYLQUINIC ACIDS
49th American Society for Mass Spectrometry Conference on Mass Spectrometry and Allied Topics, year: 2001
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New and facile method of preparation of the anti-HIV-1 agent, 1,3-dicaffeoylquinic acid
Tetrahedron Letters, year: 2001, volume: 42, edition: 19
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Stanovení biologicky aktivních látek v léčivých rostlinách pomocí kapilární elektrochromatografie
Sborník abstrakt 5. setkání biochemiků a molekulárních biologů, year: 2001
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Využití micelární elektrokinetické kapilární chromatografie pro analýzu extraktu schizandry činské
Sborník příspěvků 5.Pracovního setkání biochemiků a molekulárních biologů, year: 2001
2000
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ANTIOXIDAČNÍ PRINCIPY ROSTLINNÉHO DRUHU SCUTELLARIA BAICALENSIS
Sborník abstraktů Konference Pokroky v organické, bioorganické a farmaceutické chemii - Chemické listy, year: 2000
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Antiradical phenolic compounds from Cynara cardunculus
In Polyphenols Communication 2000. XX th International Conference on Polyphenols, year: 2000
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ANTIRADIKÁLOVÁ AKTIVITA CAFFEOYLCHINOVÝCH KYSELIN Z CYNARA CARDUNCULUS
Sborník abstraktů Konference Pokroky v organické, bioorganické a farmaceutické chemii - Chemické listy, year: 2000
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Application of Micellar Electrokinetic Chromatography for the Analysis of Artichoke Extract.
Biochemie a molekulární biologie na prahu nového tisíciletí, year: 2000
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Capillary Electrochromatography in Polyacrylamide Based Monolithic Capillary Columns
Book of Abstract, International Symposium on Capillary Electrophoresis, ITP 2000, year: 2000